Current position:Home > Selling > Vorinostat(SAHA)
CAS No:149647-78-9 N'-hydroxy-N-phenyloctanediamide
Add to My Favorites

Vorinostat(SAHA)

  • CAS No.: 149647-78-9
  • Weight: 264.3202
  • Formula: C14H20N2O3
  • Melting Point: 161-162°C
  • Place of Orign: Shanghai,,China

Supplier Details

View the Seller's Store
Product Details
Company Profile

Item specifics

  • Product Name.:Vorinostat(SAHA)
  • CAS No: 149647-78-9
  • Weight: 264.3202
  • Formula: C14H20N2O3
  • Melting Point: 161-162°C
  • Boiling Point: °Cat760mmHg
  • Density: 1.174 g/cm3

Details

Suberoylanilide hydroxamic acid (SAHA). Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. Vorinostat efficiently suppressed MES-SA cell growth at a low dosage (3 渭M) already after 24 hours treatment. Decrease of cell survival was even more pronounced after prolonged treatment and reached 9% and 2% after 48 and 72 hours of treatment, respectively. Colony forming capability of MES-SA cells treated with 3 渭M vorinostat for 24 and 48 hours was significantly diminished and blocked after 72 hours

Permanent link:

Send message to this supplier

CAS No:149647-78-9 N'-hydroxy-N-phenyloctanediamide

- Enter between 20 to 3,000 characters. English only.
Your message must be between 20-2000 characters.English only.

Look for similar items

  • Home > Pharmaceuticals and Biochemicals > Pharmaceutical

    • Related Products