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CAS No 149647-78-9 , N'-hydroxy-N-phenyloctanediamide

  • Name: N'-hydroxy-N-phenyloctanediamide
  • Synonyms: 149647-78-9; Suberanilohydroxamic acid;N'-hydroxy-N-phenyloctanediamide; suberoylanilide hydroxamic acid; Zolinza; SAHA cpd; N-hydroxy-N'-phenyloctanediamide;SAHA;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.174 g/cm3
  • Refractive index: 1.566
  • Water Solubility: Soluble in ethanol (0.25 mg/ml), DMSO & DMF (20 mg/ml)
  • Flash Point: °C
  • Molecular Weight: 264.3202
  • InchiKey: WAEXFXRVDQXREF-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/
    h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
  • Molecular Formula: C14H20N2O3
  • Molecular Structure:CAS No:149647-78-9 N'-hydroxy-N-phenyloctanediamide

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References of N'-hydroxy-N-phenyloctanediamide
Title: Vorinostat
CAS Registry Number: 149647-78-9
CAS Name: N-Hydroxy-N￠-phenyloctanediamide
Synonyms: suberoylanilide hydroxamic acid; SAHA
Molecular Formula: C14H20N2O3
Molecular Weight: 264.32
Percent Composition: C 63.62%, H 7.63%, N 10.60%, O 18.16%
Literature References: Second generation hybrid polar compound; histone deacetylase (HDAC) inhibitor that induces cell cycle arrest, differentiation and apoptosis in tumor cells. Prepn: R. Breslow et al., WO 9307148; eidem, US 5369108 (1993, 1994 both to Sloan-Kettering Inst.; Columbia Univ.); J. C. Stowell et al., J. Med. Chem. 38, 1411 (1995). Synthesis: A. Mai et al., Org. Prep. Proceed. Int. 33, 391 (2001). HTLC determn in serum: L. Du et al., Rapid Commun. Mass Spectrom. 19, 1779 (2005). In vitro antiproliferative activity: P. N. Munster et al., Cancer Res. 61, 8492 (2001). In vivo antineoplastic activity: L. A. Cohen et al., Anticancer Res. 22, 1497 (2002). Clinical pharmacokinetics and activity in cancer patients: W. K. Kelly et al., J. Clin. Oncol. 23, 3923 (2005). Review of mechanism of action: V. M. Richon et al., Blood Cells Mol. Dis. 27, 260-264 (2001); of development and therapeutic potential: R. W. Johnstone, IDrugs 7, 674-682 (2004).
Properties: White solid, mp 159-160.5°.
Melting point: mp 159-160.5°
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic.