AMG 232AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).
IC50 value: 9.1 nM (EdU proliferation assay) [1]
Target: MDM2/p53
AMG 232 was an extremely potent MDM2 inhibitor in all assays, especially in the EdU proliferation assay (IC50= 9.1 nM).
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