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CAS No:1217486-61-7 (2S)-1-N-[4-methyl-5-[2-(1,1,<br />1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,<br />3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
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BYL-719

  • CAS No.: 1217486-61-7
  • Purity: >98%
  • Weight: 441.47049
  • Formula: C19H22F3N5O2S
  • Place of Orign: Princeton,New Jersey,United States
Ms.James Gao

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Item specifics

  • Product Name.:BYL-719
  • CAS No: 1217486-61-7
  • Weight: 441.47049
  • Formula: C19H22F3N5O2S
  • Density: 1.391

Details

BYL-719BYL719 is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, ;liitle or no effect on PI3Kβ/γ/δ.

IC50 value: 5 nM [1]

Target: PI3Kα

in vitro: BYL719 inhibits the proliferation of breast cancer cell lines harboring PIK3CA mutations, correlating with inhibition of various downstream signaling components of the PI3K/Akt pathway [1].

in vivo: BYL719(>270 mg/d) shows statistically significant dose-dependent anti-tumor efficacy in PIK3CA mutant xenograft models in rodents.

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CAS No:1217486-61-7 (2S)-1-N-[4-methyl-5-[2-(1,1,<br />1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,<br />3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide

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