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CAS No:1195765-45-7 N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,<br />3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
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Dabrafenib

  • CAS No.: 1195765-45-7
  • Purity: >98%
  • Weight: 519.56241
  • Formula: C23H20F3N5O2S2
  • Place of Orign: Princeton,New Jersey,United States
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Item specifics

  • Product Name.:Dabrafenib
  • CAS No: 1195765-45-7
  • Weight: 519.56241
  • Formula: C23H20F3N5O2S2
  • Boiling Point: 653.726 °C at 760 mmHg
  • Density: 1.443

Details

DabrafenibDabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.

IC50 value: 0.8 nM (BRAFV600) [1]

Target: BRAFV600

in vitro: Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested.

Target:Calcium Channel

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CAS No:1195765-45-7 N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,<br />3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide

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