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N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1, 3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
CAS No 1195765-45-7 , N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,
3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
Name:
N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,
3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
Synonyms:
Dabrafenib; GSK2118436A; Tafinlar; 1195765-45-7; GSK-2118436; Dabrafenib (USAN); Dabrafenib [USAN:INN]; UNII-QGP4HA4G1B; SureCN806377
CAS Registry Number:
1195765-45-7
Density:
1.443
Molecular Weight:
519.56241
InchiKey:
BFSMGDJOXZAERB-UHFFFAOYSA-N
InChI:
InChI=1S/C23H20F3N5O2S2/c1-23(2,
3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35
(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
Molecular Formula:
C
23
H
20
F
3
N
5
O
2
S
2
Molecular Structure:
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2,5-difluorobenzenesulfonamide
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1195765-45-7 Dabrafenib
Dabrafenib Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. IC50 value: 0.8 nM (BRAFV600) [1] Target: BRAFV600 in vitro: Dabrafenib is sele...
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