Testosterone Acetate (Steroids)
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Molecular Structure
Detailed Description
Testosterone Acetate is the major androgenic hormone that is responsible for the growth and development of masculine characteristics. It is produced in the Leydig cells (interstitial cells) of the testes. it regulates gonadotropic secretion and wolffian duct differentiation (formation of the epididymis, vas deferens, and seminal vesicle), and stimulates skeletal muscle. It is also responsible for other male characteristics and spermatogenesis after its conversion to dihydrotestosterone by 5alpha-reductase in peripheral tissue. Testosterone is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. In addition, testosterone possesses protein anabolic properties, manifested by retention of nitrogen, calcium, phosphorus, and potassium, and is important in maintaining muscle mass and bone tissue in the adult male. It is also converted by aromatization to estradiol in peripheral tissue. It has been synthesized for replacement therapy, in the form of various esters having prolonged duration of effects, in treating male hypogonadism, cryptorchidism, frigidity, inoperable female breast cancer, oligospermia, to suppress lactation, and as an anabolic agent.
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