Sildenafil Mesylate
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Molecular Structure
Detailed Description
Sildenafil Mesylate
Synonym: (R)-(+)-[2,3-DIHYDRO-5-METHYL-3-(4-MORPHOLINYLMETHYL)PYRROLO[1,2,3-DE]-1,4-BENZOXAZIN-6-YL]-1-NAPHTHALENYLMETHANONE MESYLATE; R(+)-[2,3-DIHYDRO-5-METHYL-3-[(MORPHOLINYL)METHYL]PYRROLO[1,2,3-DE]-1,4-BENZOXAZINYL]-(1-NAPHTHALENYL)METHANONE MESYLATE; R(+)-WIN 55,212-2 MESYLATE; R(+)-WIN 55,212-2 ,MESYLATE HIGH AFFINIT Y CANNABI; (R)-(+)-(2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1.2.3-de]-1,4-benzoxazin-6-yl)-1-naphthalenylmethanonemesy; 212-2Mesylate; [(3R)-5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl](naphthalen-1-yl)methanone methanesulfonate; Sildenafil Mesylate
InChI: InChI=1/C27H26N2O3.CH4O3S/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28;1-5(2,3)4/h2-11,20H,12-17H2,1H3;1H3,(H,2,3,4)/t20-;/m1./s1
CAS No.: 131543-23-2
M.F.: C28H30N2O6S
M.W.: 522.6126
Assay: 99%
Content/ Purity: 99%
Storage:Store in Cool and dry place
Sildenafil: 0.132%
Boiling point: 627.7 ° C at 760 mmHg
Flash point: 333.4 ° C
Steam pressure: 1.14E-15mmHg at 25 ° C
Heavy Metals: < 10PPM
Water Content: 0.51%
Residue on Ignition: 0.05%
Solubility: 0.1 M HCl: 0.25 mg/mL
Appearance: white to almost white crystalline powder, odorless, a little acerbity, soluble in water, ethanol
Use: It is pharmaceutical raw material, indicated for the treatment of erectile dysfunction. pharmaceutical material, hormone. As a cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) selective inhibitor, penile smooth muscle relaxation allows rapid erection. Sildenafil is cheap, is the development and production of low-cost classes available kidney yang-like the perfect material for medicine and health products.
Description:
Sildenafil Mesylate Assay: 99% Packing:foil bagsAppearance: White or white crystalline powder, odorless, bitter astringent taste, soluble in water and ethanolUsage: Pharmaceutical raw materials, aphrodisiac
More Introduction:
Sildenafil Mesylate, same as Sildenafil is an inhibitor of type 5 -cGMP phosphodiesterase relaxing and smoothing muscle cells of the corpus cavernosum which leads to penile erection. This relaxation may be mediated by nitric oxide via cyclic guanosine monophosphate (cGMP).
Applications:
Viagra treats erectile dys function and works by relaxing muscles and increases blood flow to particular areas of the body (in this case, the penis, specifically). Its effects last up to four hours. The most common side effects of Viagra are headache, facial flushing, and upset stomach. Rarely, blurred vision, or sensitivity to light may briefly occur.
As well as treating impotence, Sildenafil Citrate can also be effective in treating Pulmonary Arterial Hypertension (PAH). Similarly to how it acts to relax muscles of the penis, it relaxes arterial walls; therefore, reducing resistance and pressure in the arteries.
Sildenafil Citrate is solely active in relaxing muscles and increasing blood flow to the heart, lungs and penis due to PDE-5, yet vasodilation is not increased in other parts of the body.
Technical Data: In studies where Viagra was administered to over 3700 patients, 19-87 years old in world wide clinical trials. More than 550 patients received treatment post 1 year. 2.5% of the Viagra subjects and 2.3% of the placebo subjects reported adverse effects, which were all considered mild. These reported side effects included abnormal or blurred vision and increased sensitivity to light.
All other negative reactions reported, including URI, flu symptoms, back pain and arthralgia, occurred at a rate of less than 2% and equally common in the placebo and Viagra administered groups. Effects worsened and were reported more frequently as dosages increased.
Other studies measured duration of sexually stimulated erection using a Rigiscan device. Duration of rigidity was increased by 60% with Viagra use.
The use of the products:
1.Sildenafil mesylate compared to sildenafil citrate has the advantages of small dosage, side effects is very small, and is soluble in water and ethanol.
2. Sildenafil mesylate is the same cyclic guanosine monophosphate (cGMP) type 5 phosphodiesterase (PDE5) specific inhibitor, can make the penile smooth muscle relaxation, the rapid erection.
- Sildenafil Mesylate
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