Z)-Guggulsterone

• Product NameZ)-Guggulsterone
  CAS No.39025-23-5
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  Molecular Structure

Detailed Description

Product Name:(Z)-Guggulsterone
Synonyms:4,17(20)-(CIS)-PREGNADIEN-3,16-DIONE;GUGULSTERONE;GUGGULESTERONE Z;GUGGULSTERONE;GUGGULSTERONE Z;GUGGULSTERONE (Z FORM);CIS-4,17(20)-PREGNADIENE-3,16-DIONE;CIS GUGGULSTERONE
CAS:39025-23-5
MF:C21H28O2
MW:312.45
Usage:Z-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent.
Biological Activity:Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (K i values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (K i = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signalling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo . More active isomer of Guggulsterone (Pregna-4,17(20)-diene-3,16-dione ).
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• Z)-Guggulsterone