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Eltrombopag (SB-497115-GR)

  • CAS No:496775-61-2 3-[(5E)-5-[[2-(3,<br />4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]hydrazinylidene]-6-<br />oxocyclohexa-1,3-dien-1-yl]benzoic acid
    Molecular Structure

    Detailed Description

    Eltrombopag (SB-497115-GR, Promacta, Revolade) is a small molecule agonist of the c-mpl (TpoR) receptor with an IC50 of 0.69 uM for the inhibition of hERG K+ channel tail current. In preclinical studies, the compound was shown to interact selectively with the thrombopoeitin receptor, leading to activation of the JAK-STAT signaling pathway and increased proliferation and differentiation of megakaryocytes. Animal studies confirmed that administration could increase platelet counts. More information please visit the website: http://www.creative-enzymes.com/product/Eltrombopag-SB497115GR-_2321.html



  • Eltrombopag (SB-497115-GR)
  • Eltrombopag (SB-497115-GR)