Clomid (Clomiphene Citrate)
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Molecular Structure
Detailed Description
Product Name: Clomid (Clomiphene Citrate)
CAS: 50-41-9
Purity: 99%
Appearance: white powder
EINECS No.: 200-035-3
M.F.: C32H36ClNO8
M.W: 598.09
Appearance: White or off-white powder
Identification: UV conform
Organic nitrogenous: Up to standard
Citrate: Up to standard
Water: NMT 1.0%
Heavy water: NMT 0.002%
Related Impurities: Related compound A: NMT 2.0%
Individual impurity: NMT 0.5%
(Z) isomer: Up to standard
Organic Volatile Impurities: Up to standard
Assay: 98.0%~102.0%
Standard: USP36
Details:
Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist - the cofactor used in that tissue cannot bind and so the receptor remains inactive - and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.
- Clomid (Clomiphene Citrate)
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