high quality Megestrol acetate powder

• Product Namehigh quality Megestrol acetate powder
  CAS No.595-33-5
  Purity98%min.
  Min Quantity500Kilograms
  Price1~1000
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  Molecular Structure

Detailed Description

CAS NO.: 595-33-5
EINECS: 209-864-5
Assay: 99%
Molecular Formula:C24H32O4
Molecular Weight:384.51
Quality Standard: EP5/USP34
Packing:5kg/tin,20kg/drum
Appearance: White or light yellow crystalline powder (methanol), odorless and tasteless. Melting point 214-216 ℃. Soluble in acetone, slightly soluble in ethanol, ethyl ether, insoluble in water

Usage:
1. Mainly used for short-acting oral contraceptives, also can be used for intramuscular injection of long-acting contraceptives.
2. For the treatment of dysmenorrhea, amenorrhea, dysfunctional uterine bleeding, endometriosis and endometrial adenocarcinoma


Product Description
Megestrol acetate (INN, USAN, BAN, JAN) (abbreviated as MGA or MA, and sold mainly under the brand names Megace and Megace ES), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.

Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound.

Megestrol acetate has powerful antiandrogenic and antiestrogenic effects in humans at sufficient doses, capable of decreasing circulating androgen and estrogen concentrations to castrate levels in both sexes and significantly lowering the expression of the androgen receptor (AR) and the estrogen receptor (ER) in the body; as an example, one study in men with benign prostatic hyperplasia who were treated with 120-160 mg of megestrol acetate per day for 3 to 11 days found average decreases in AR quantity of 73% and 86% in the cytoplasm and nucleus of prostatic cells, respectively.[12] These actions are likely the result of a strong activation of the PR, which suppresses the secretion of the gonadotropins-peptide hormones responsible for signaling the body to produce not only progesterone but also the androgens and the estrogens-from the pituitary gland as a form of negative feedback inhibition, and hence downregulates the hypothalamic-pituitary-gonadal (HPG) axis, resulting in decreased levels of the sex hormones and their associated enzymes, carriers (e.g., sex hormone-binding globulin), and receptors.It is the antiandrogenic and antiestrogenic effects of megestrol acetate mediated by suppression of the HPG axis that are believed to be largely responsible for its beneficial effects against androgen and estrogen-sensitive cancers, respectively.

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• high quality Megestrol acetate powder