THZ1

• Product NameTHZ1
  CAS No.1604810-83-4
  Purity>98%
  Min Quantity
  Price~
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Detailed Description

THZ1THZ1 is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell's proliferation with IC50 of 50 nM.

IC50 value: 3.2 nM (Kd for CDK7)[1]

Target: CDK7

THZ1 has the unprecedented ability to target a remotecysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.

Cancer cell-line profiling indicates that a subset of cancer cell lines,

including human T-cell acute lymphoblastic leukaemia (T-ALL), have exceptional sensitivity to THZ1.

Target:CDK

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