PF-3084014

• Product NamePF-3084014
  CAS No.1290543-63-3
  Purity>98%
  Min Quantity
  Price~
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Detailed Description

PF-3084014PF-3084014 is a novel γ-secretase inhibitor that reduces amyloid-beta (Abeta) production with an in vitro IC(50) of 1.2 nM (whole-cell assay) to 6.2 nM (cell-free assay).

IC50 Value: 1.2 nM (whole-cell assay); 6.2 nM (cell-free assay) [1]

Target: γ-secretase

in vitro: The ability of PF-03084014 to inhibit gamma-secretase activity was shown by the reduction of endogenous NICD levels and by the downregulation of Notch target genes Hes-1 and c-Myc in the T-cell acute lymphoblastic leukemia (T-ALL) cell line HPB-ALL.

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