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ABT-737;ABT 737;ABT737

  • CAS No:852808-04-9 4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-<br />(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]<br />sulfonylbenzamide
    Molecular Structure

    Detailed Description

    ABT-737 is a pan-Bcl-2 inhibitor that has a wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts. Increased expression of the Bcl-2 family of proteins in cancers has been associated with chemotherapy resistance, inhibiting Bcl-2 or Bcl-XL overexpression could potentially induce apoptosis in cancer cells while having minimal effects on normal cells.

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