Irinotecan
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Molecular Structure
Detailed Description
Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. It is used for the treatment of colon and rectum cancers. It binds to topoisomerase I-DNA complex, preventing religation of the DNA strand and leading to double-strand DNA breakage and cell death.https://www.bocsci.com/irinotecan-cas-97682-44-5-item-84-101283.html
- Irinotecan