BIOLOG is an innovative and scientifically orientated enterprise, which is specialized in tools for signal transduction research. The company has its focus on nucleotide chemistry with special emphasis on cyclic nucleotide-based modulators of respective protein kinases, phosphodiesterases and ion channels.BIOLOG's portfolio for the research reagent market comprises 450+ different rare nucleosides, nucleotides and nucleobases, including probably the largest collection of cyclic AMP and cyclic GMP analogs which differ in terms of potency, membrane permeability, receptor specificity and kinase isozyme selectivity as well as phosphodiesterase-stability, or which carry a fluorescent label. High purity nucleoside triphosphate analogs, as well as widely used tools such as dibutyryl-cAMP, 8-bromo-cAMP or cyclic ADP ribose are produced in bulk quantities. Additional products are nucleotide ligands for affinity chromatography or for chip surfaces, as well as compound libraries. Custom nucleotide syntheses, especially in the field of modified mono-, di- and triphosphates as well as fluorescence labeling are other main activities of the company.At BIOLOG there is permanent research on novel specific modulators of cyclic nucleotide-responsive receptors which has already led to several generally accepted tools for signal transduction research, such as PKA and PKG inhibitors as well as Epac-specific agonists.The company collaborates scientifically with other research groups as well, mainly on receptor mapping studies and the development of novel enzyme modulators by means of nucleotide analogs.Since most of the products offered are synthesized in own fully equipped laboratories there is a strong background in nucleotide chemistry and corresponding scientific areas.