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CAS No 99294-94-7 , Teriparatide acetate hydrate

  • Name: Teriparatide acetate hydrate
  • Synonyms: Parathar acetate;Teriparatide acetate hydrate; UNII-9959P4V12N; Teriparatide acetate hydrate; Teriparatide acetate [USAN:JAN]; Teriparatide acetate; 99294-94-7;
  • CAS Registry Number:
  • Molecular Weight: 4177.7671
  • InchiKey: BUUKFBVDKSFMHN-LKMAISLMSA-N
  • InChI: InChI=1S/C181H291N55O51S2.C2H4O2/c1-21-96(18)146(236-160(267)114(48-53-
    141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)
    103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90
    (6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-
    100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)
    201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-
    202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171
    (278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-
    139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94
    (14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-
    104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-
    33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107
    (41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133
    (186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176
    (283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170
    (277)230-130(179(286)287)68-97-35-23-22-24-36-97;1-2(3)4/h22-26,35-38,
    77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,
    182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,
    190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,
    258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,
    281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,
    259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,
    265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,
    277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,
    267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,
    198)(H4,193,194,199);1H3,(H,3,4)/t96-,103-,105-,106-,107-,108-,109-,
    110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,
    124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-;/m0./s1
  • Molecular Formula: C183H295N55O53S2
  • Molecular Structure:CAS No:99294-94-7 Teriparatide acetate hydrate

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99294-94-7 Teriparatide Acetate

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References of Teriparatide acetate hydrate
Title: Teriparatide Acetate
CAS Registry Number: 99294-94-7
Synonyms: hPTH 1-34 acetate
Manufacturers' Codes: MN-10T
Trademarks: Parathar (Rorer); Forteo (Lilly)
Line Formula: C181H292N55O51S2.yC2H4O2.xH2O
Literature References: Synthetic, biologically active polypeptide consisting of the 1-34 amino-terminal fragment of human parathyroid hormone (hPTH), q.v. Amino acid sequence: H. B. Brewer et al., Proc. Natl. Acad. Sci. USA 69, 3585 (1972). Prepn: R. H. Andreatta et al., Helv. Chim. Acta 56, 470 (1973). Revised structure: H. D. Niall et al., Proc. Natl. Acad. Sci. USA 71, 384 (1974). Prepn: R. L. Colescott, DE 2649727; idem, DE 2649848; G. W. Tregear, US 4086196 (1977, 1977, 1978 all to Armour Pharm.). Solid phase synthesis and biological activity: G. W. Tregear et al., Z. Physiol. Chem. 355, 415 (1974). Solution synthesis and biological activity: M. Takai et al., Pept. Chem. 17, 187 (1980). Clinical pharmacology: R. M. Neer et al., J. Clin. Endocrinol. Metab. 38, 420 (1977). RIA determn in plasma: J. M. Zanelli et al., J. Immunoassay 1, 289 (1980). Clinical pharmacokinetics: G. N. Kent et al., Clin. Sci. 68, 171 (1985). Clinical evaluation in osteoporosis: J. Reeve et al., Br. Med. J. 280, 1340 (1980); D. M. Slovik et al., J. Clin. Invest. 68, 1261 (1981). Diagnostic use: T. Igarashi et al., Pharmatherapeutica 3, 79 (1982); L. E. Mallette et al., J. Clin. Endocrinol. Metab. 67, 964 (1988). Review of diagnostic use in modified Ellsworth-Howard test: L. E. Mallette, Ann. Intern. Med. 109, 800-804 (1988); of pharmacology and clinical efficacy: H. Dobnig, Expert Opin. Pharmacother. 5, 1153-1162 (2004).
Therap-Cat: Treatment of osteoporosis. Diagnostic aid (hypocalcemia).
Keywords: Antiosteoporotic; Calcium Regulator; Diagnostic Aid.