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CAS No 992-21-2 , Lymecycline

  • Name: Lymecycline
  • Synonyms: Tetramyl; Tertamyl; Vebicyclysal;Lymecycline; Tetralysal; Tetracyclinemethylenelysine; Tetracycline-L-methylenelysine; Tetralisal;(+)-N-(5-Amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide;
  • CAS Registry Number:
  • Flash Point: 462.1°C
  • Boiling Point: 840.5°C at 760 mmHg
  • Density: 1.53
  • Refractive index: 1.693
  • Safety Statements: Poison by intravenous route. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 462.1°C
  • EINECS: 213-592-2
  • Molecular Weight: 602.64
  • InChI: InChI=1/C29H38N4O10/c1-28(42)13-7-6-9-17(34)18(13)22(35)19-14(28)11-15-21(33(2)3)23(36)20(25(38)29(15,43)24(19)37)26(39)32-12-31-16(27(40)41)8-4-5-10-30/h6-7,9,14-16,21,31-32,34-35,39,42-43H,4-5,8,10-12,30H2,1-3H3,(H,40,41)/b26-20+/t14?,15-,16?,21-,28+,29-/m0/s1
  • Molecular Formula: C29H38N4O10
  • Molecular Structure:CAS No:992-21-2 Lymecycline

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992-21-2 L-Lysine,N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-

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References of Lymecycline
Title: Lymecycline
CAS Registry Number: 992-21-2
CAS Name: N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-L-lysine
Synonyms: tetracyclinemethylene lysine; N-lysinomethyltetracycline
Trademarks: Tetralisal (Galderma); Tetralysal (Galderma)
Molecular Formula: C29H38N4O10
Molecular Weight: 602.63
Percent Composition: C 57.80%, H 6.36%, N 9.30%, O 26.55%
Literature References: Semi-synthetic antibiotic related to tetracycline, q.v. Prepn: R. K. Blackwood, K. J. Brunings, US 3042716 (1962 to Pfizer); F. Lauria, W. Logemann, DE 1134071 (1962 to Carlo Erba), C.A. 58, 492 (1963); E. Tubaro, E. Raffaldoni, Boll. Chim. Farm. 100, 9 (1961). Clinical pharmacokinetics: A. Schreiner, A. Digranes, Chemotherapy (Basel) 31, 261 (1985). Comparison with doxycycline of phototoxic potential: M. Bjellerup, B. Ljunggren, Br. J. Dermatol. 130, 356 (1994). Clinical trial in acne: L. Bossuyt et al., Eur. J. Dermatol. 13, 130 (2003); of combination with adapalene: W. J. Cunliffe et al., J. Am. Acad. Dermatol. 49, S218 (2003).
 
Derivative Type: Sodium salt
Molecular Formula: C29H37N4NaO10
Molecular Weight: 624.61
Percent Composition: C 55.76%, H 5.97%, N 8.97%, Na 3.68%, O 25.62%
Properties: uv max (CH3OH): 376 nm.
Absorption maximum: uv max (CH3OH): 376 nm
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Tetracyclines.