Home > Name List By 5 > 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3, 4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

CAS No 97322-87-7 , 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,
4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

  • Name: 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,
    4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
  • Synonyms: Rezulin (TN); Noscal; CS 045; Prelay; Resulin; Romglizone; CS-045; Romozin;Rezulin;5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,
    4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;
  • CAS Registry Number:
  • Melting Point: 184-186°C
  • Flash Point: 351.2°C
  • Boiling Point: 657°Cat760mmHg
  • Density: 1.266g/cm3
  • Safety Statements:
    Safety Statements 22-24/25
    WGK Germany 2
    RTECS XJ5813130
  • Flash Point: 351.2°C
  • Molecular Weight: 441.53988
  • InchiKey: GXPHKUHSUJUWKP-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,
    30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,
    9-12H2,1-4H3,(H,25,27,28)
  • Risk Statements: S22;S24/25
  • Molecular Formula: C24H27NO5S
  • Molecular Structure:CAS No:97322-87-7 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,<br />4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

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97322-87-7 TROGLITAZONE

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References of 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,
4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Title: Troglitazone
CAS Registry Number: 97322-87-7
CAS Name: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
Synonyms: (±)-5-[4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione; romglizone
Manufacturers' Codes: CS-045; CI-991
Trademarks: Noscal (Sankyo); Prelay (Sankyo); Rezulin
Molecular Formula: C24H27NO5S
Molecular Weight: 441.54
Percent Composition: C 65.28%, H 6.16%, N 3.17%, O 18.12%, S 7.26%
Literature References: Oral hypoglycemic agent which improves insulin sensitivity and decreases hepatic glucose production. Prepn: JP Kokai 85 51189; T. Yoshioka et al., US 4572912 (1985, 1986 both to Sankyo); T. Yoshioka et al., J. Med. Chem. 32, 421 (1989). Mechanism of action studies: T. P. Ciaraldi et al., Metabolism 39, 1056 (1990); M. Kellerer et al., Diabetes 43, 447 (1994). Clinical evaluation: T. Kuzuya et al., Diabetes Res. Clin. Pract. 11, 147 (1991). Clinical metabolic effects: S. L. Suter et al., Diabetes Care 15, 193 (1992).
Properties: Crystals from benzene-acetone, mp 184-186°.
Melting point: mp 184-186°
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Thiazolidinediones; Insulin Sensitizer.