Home > Name List By other > (8S,11R,13R,14S, 17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)-13- methyl-1,2,6,7,8,11,12,14,15,16-decahy...

CAS No 96346-61-1 , (8S,11R,13R,14S,
17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)-13-
methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

  • Name: (8S,11R,13R,14S,
    17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)-13-
    methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
  • Synonyms: CCRIS 6530; ZK-98299; Onapristone (INN);(8S,11R,13R,14S,
    17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)-13-
    methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one;Onapristone [INN]; Onapristona [Spanish]; ZK 299; Onapristonum [Latin]; 96346-61-1; ZK 98299;
  • CAS Registry Number:
  • Melting Point: 449.625
  • Density: 1.19 g/cm3
  • Refractive index: 1.615
  • Molecular Weight: 449.62486
  • InchiKey: IEXUMDBQLIVNHZ-YOUGDJEHSA-N
  • InChI: InChI=1S/C29H39NO3/c1-28-18-25(19-5-8-21(9-6-19)30(2)3)27-23-12-10-22
    (32)17-20(23)7-11-24(27)26(28)13-15-29(28,33)14-4-16-31/h5-6,8-9,17,
    24-26,31,33H,4,7,10-16,18H2,1-3H3/t24-,25+,26-,28+,29+/m0/s1
  • Molecular Formula: C29H39NO3
  • Molecular Structure:CAS No:96346-61-1 (8S,11R,13R,14S,<br />17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)-13-<br />methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

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96346-61-1 Estra-4,9-dien-3-one,11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)-, (11b,13a,17a)-

  • China Bo Jia Science and Technology (Wuhan) Co., Ltd. [Manufacturers]
  • Tel: 02787526690-8155
  • Fax: 86-027-87526527
  • Address: Wuhan City, Hubei Province Luo Yu Road, Hongshan No. 424 Technology Innovation Center, 14 Floor, Block A wuhan,hubeiChina
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References of (8S,11R,13R,14S,
17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)-13-
methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Title: Onapristone
CAS Registry Number: 96346-61-1
CAS Name: (11b,13a,17a)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)estra-4,9-dien-3-one
Synonyms: 11b-(4-dimethylaminophenyl)-17a-hydroxy-17b-(3-hydroxypropyl)-13a-methyl-4,9-gonadien-3-one
Manufacturers' Codes: ZK-98299
Molecular Formula: C29H39NO3
Molecular Weight: 449.62
Percent Composition: C 77.47%, H 8.74%, N 3.12%, O 10.68%
Literature References: Progesterone receptor antagonist. Prepn: G. Neef et al., EP 129499; eidem, US 4780461 (1984, 1988 both to Schering AG); idem et al., Steroids 44, 349 (1984). HPLC determn in plasma and serum: C. Zurth, F. Kagels, J. Chromatogr. 532, 115 (1990). In vitro effect on breast cancer cells: S. Classen et al., J. Steroid Biochem. Mol. Biol. 45, 315 (1993). Mechanism of action study: D. P. Edwards et al., ibid. 53, 449 (1995). Clinical antifolliculotrophic effect: H. B. Croxatto et al., Hum. Reprod. 9, 1442 (1994).
Properties: Amorphous glass. [a]D25 +446.2° (c = 0.51 in chloroform).
Optical Rotation: [a]D25 +446.2° (c = 0.51 in chloroform)
Therap-Cat: Antiprogestin; antineoplastic (hormonal).
Keywords: Antineoplastic (Hormonal); Antiprogestins; Antiprogestin.