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CAS No 96-83-3 , 2-[(3-amino-2,4,6-triiodophenyl)methyl]butanoic acid

  • Name: 2-[(3-amino-2,4,6-triiodophenyl)methyl]butanoic acid
  • Synonyms: 2-[(3-amino-2,4,6-triiodophenyl)methyl]butanoic acid; Polognost; Choladine; Jopanoic acid; Bilijodon; Cistobil; Telepaque;Iodopanoic acid; Iopagnost; Cholevid;
  • CAS Registry Number:
  • Melting Point: 153 °C
  • Flash Point: 273.8°C
  • Boiling Point: 529.1°Cat760mmHg
  • Density: 2.426g/cm3
  • Refractive index: 1.732
  • Safety Statements: Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by ingestion: dermatitis, nausea or vomiting, thrombocytopenia. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of I and NOx.
  • Flash Point: 273.8°C
  • EINECS: 202-539-9
  • Molecular Weight: 570.93189
  • InchiKey: OIRFJRBSRORBCM-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H12I3NO2/c1-2-5(11(16)17)3-6-7(12)4-8(13)10(15)9(6)14/h4-5H,
    2-3,15H2,1H3,(H,16,17)
  • Risk Statements: 20/21/22
  • Molecular Formula: C11H12I3NO2
  • Molecular Structure:CAS No:96-83-3 2-[(3-amino-2,4,6-triiodophenyl)methyl]butanoic acid
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96-83-3 IOPANOIC ACID

  • IOPANOIC ACID
  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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96-83-3 IOPANOIC ACID

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of 2-[(3-amino-2,4,6-triiodophenyl)methyl]butanoic acid
Title: Iopanoic Acid
CAS Registry Number: 96-83-3
CAS Name: 3-Amino-a-ethyl-2,4,6-triiodobenzenepropanoic acid
Synonyms: 3-amino-a-ethyl-2,4,6-triiodohydrocinnamic acid; iodopanoic acid; 3-(3-amino-2,4,6-triiodophenyl)-2-ethylpropanoic acid; 3-(3-amino-2,4,6-triiodophenyl)-2-ethylpropionic acid
Trademarks: Cistobil (Bracco); Colepax; Telepaque (Winthrop); Teletrast (Astra)
Molecular Formula: C11H12I3NO2
Molecular Weight: 570.93
Percent Composition: C 23.14%, H 2.12%, I 66.68%, N 2.45%, O 5.60%
Literature References: Oral radiocontrast medium. Prepn: S. Archer, US 2705726 (1955 to Sterling Drug). Optical resolution: Pitré, Boveri, J. Med. Chem. 11, 406 (1968). Toxicity data: P. Tirone, G. Rosati, Farmaco Ed. Prat. 31, 397 (1976). Review of pharmacology and clinical efficacy in oral cholecystography: R. N. Berk et al., N. Engl. J. Med. 290, 204 (1974). Comprehensive description: D. Pitre, Anal. Profiles Drug Subs. 14, 181-206 (1985).
 
Derivative Type: dl-Form
Properties: Cream-colored solid, mp 155.2-157°. pKa 4.8. Insol in water. Sol in dil alkali, in 95% alc, in other organic solvents. LD50 in mice, rats (mg/kg): 285, 320 i.v.; 1540, 2870 orally (Tirone).
Melting point: mp 155.2-157°
pKa: pKa 4.8
Toxicity data: LD50 in mice, rats (mg/kg): 285, 320 i.v.; 1540, 2870 orally (Tirone)
 
Derivative Type: l-Form
CAS Registry Number: 17879-97-9
Properties: Crystals, mp 162-163°. [a]D20 -5.2 ± 0.1° (c = 2 in ethanol).
Melting point: mp 162-163°
Optical Rotation: [a]D20 -5.2 ± 0.1° (c = 2 in ethanol)
 
Derivative Type: d-Form
CAS Registry Number: 17879-96-8
Properties: Crystals, mp 162°. [a]D20 +5.1 ± 0.1° (c = 2 in ethanol).
Melting point: mp 162°
Optical Rotation: [a]D20 +5.1 ± 0.1° (c = 2 in ethanol)
 
Derivative Type: Sodium salt
CAS Registry Number: 2497-78-1
Trademarks: Bilijodon-Natrium
 
Therap-Cat: Diagnostic aid (radiopaque medium?cholecystographic).
Keywords: Diagnostic Aid (Radiopaque Medium).