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CAS No 95751-30-7 , Charybdotoxin

  • Name: Charybdotoxin
  • Synonyms: 95751-30-7;Charybdotoxin; Quinquestriatus Toxin; 115422-61-2;CTX Toxin; Charybdotoxin (reduced);
  • CAS Registry Number:
  • Water Solubility: Solution at 1 mg/ml in Water
  • Molecular Weight: 4295.88648
  • InchiKey: CNVQLPPZGABUCM-LIGYZCPXSA-N
  • InChI: InChI=1S/C176H277N57O55S7/c1-81(2)58-106-149(263)213-110(62-91-67-191-
    80-197-91)152(266)215-112(64-127(183)246)156(270)231-135(85(8)240)170
    (284)219-114(69-234)157(271)200-95(36-25-54-192-174(185)186)138(252)196-
    68-130(249)199-96(32-17-21-50-177)139(253)222-120-75-291-295-79-124(226-
    159(273)116(71-236)218-167(281)132(82(3)4)228-155(269)113(65-128(184)
    247)216-169(283)134(84(7)239)230-154(268)108(59-88-28-13-12-14-29-88)
    210-145(259)102-44-47-129(248)198-102)166(280)232-137(87(10)242)172(286)
    233-136(86(9)241)171(285)220-115(70-235)158(272)204-98(34-19-23-52-179)
    141(255)206-104(45-48-131(250)251)147(261)225-122-77-292-290-74-119(223-
    143(257)99(35-20-24-53-180)201-140(254)97(33-18-22-51-178)203-153(267)
    111(63-126(182)245)214-148(262)105(49-57-289-11)208-162(120)276)161(275)
    205-101(38-27-56-194-176(189)190)144(258)224-121(164(278)211-107(60-89-
    39-41-92(243)42-40-89)150(264)221-118(73-238)173(287)288)76-293-294-78-
    123(163(277)207-103(43-46-125(181)244)146(260)202-100(142(256)209-106)
    37-26-55-193-175(187)188)227-168(282)133(83(5)6)229-160(274)117(72-237)
    217-151(265)109(212-165(122)279)61-90-66-195-94-31-16-15-30-93(90)94/
    h12-16,28-31,39-42,66-67,80-87,95-124,132-137,195,234-243H,17-27,32-38,
    43-65,68-79,177-180H2,1-11H3,(H2,181,244)(H2,182,245)(H2,183,246)(H2,
    184,247)(H,191,197)(H,196,252)(H,198,248)(H,199,249)(H,200,271)(H,201,
    254)(H,202,260)(H,203,267)(H,204,272)(H,205,275)(H,206,255)(H,207,
    277)(H,208,276)(H,209,256)(H,210,259)(H,211,278)(H,212,279)(H,213,
    263)(H,214,262)(H,215,266)(H,216,283)(H,217,265)(H,218,281)(H,219,
    284)(H,220,285)(H,221,264)(H,222,253)(H,223,257)(H,224,258)(H,225,
    261)(H,226,273)(H,227,282)(H,228,269)(H,229,274)(H,230,268)(H,231,
    270)(H,232,280)(H,233,286)(H,250,251)(H,287,288)(H4,185,186,192)(H4,187,
    188,193)(H4,189,190,194)/t84-,85-,86-,87-,95+,96+,97+,98+,99+,100+,101+,
    102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113+,114+,115+,
    116+,117+,118+,119+,120+,121+,122+,123+,124+,132+,133+,134+,135+,136+,
    137+/m1/s1
  • Molecular Formula: C176H277N57O55S7
  • Molecular Structure:CAS No:95751-30-7 Charybdotoxin

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95751-30-7 SC-200979 CHARYBDOTOXIN

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References of Charybdotoxin
Title: Charybdotoxin
CAS Registry Number: 95751-30-7
Synonyms: ChTX; CTX
Molecular Formula: C176H277N57O55S7
Molecular Weight: 4295.89
Percent Composition: C 49.21%, H 6.50%, N 18.58%, O 20.48%, S 5.22%
Literature References: Peptide inhibitor of K+ channels isolated from the venom of the scorpion Leiurus quinquestriatus var. hebraeus. Single chain of 4.3 kDa comprised of 37 amino acids with 3 disulfide linkages. Identification: C. Miller et al., Nature 313, 316 (1985). Purification and amino acid sequence: G. Gimenez-Gallego et al., Proc. Natl. Acad. Sci. USA 85, 3329 (1988). Synthesis: E. E. Sugg et al., J. Biol. Chem. 265, 18745 (1990); P. Lambert et al., Biochem. Biophys. Res. Commun. 170, 684 (1990). NMR structural study: F. Bontems et al., Eur. J. Biochem. 196, 19 (1991). Mechanism of channel block: R. MacKinnon, C. Miller, J. Gen. Physiol. 91, 335 (1988). Characterization of binding sites: J. Vázquez et al., J. Biol. Chem. 264, 20902 (1989); J. Vázquez et al., ibid. 265, 15564 (1990). Use as probe for K+ channels: M. Garcia, G. Gimenez-Gallego, US 4960867 (1990 to Merck & Co.).
Properties: Extinction coefficient: 1.52 (mg/ml)-1cm-1 at 280 nm; 15.05 (mg/ml)-1cm-1 at 215 nm.
Use: Biochemical probe.