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CAS No 93384-43-1 , Botulin A

  • Name: Botulin A
  • Synonyms: Botulinum toxin A.;Botulin A;
  • CAS Registry Number:
  • Transport: UN 3172 6.1/PG 1
  • Melting Point: 85.5 to 86.5 deg C
  • Safety Statements:
    Hazard Codes T+,B
    Risk Statements 26/27/28-36/38
    Safety Statements 26-28-36/37-45
    RIDADR UN 3172 6.1/PG 1
    WGK Germany 3
    RTECS ED9300000
    HazardClass 6.1(a)
    PackingGroup I
  • Hazard Symbols: T+: Very toxic;
  • EINECS: 297-253-4
  • Molecular Weight: 0
  • InChI: InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
  • Risk Statements: 26/27/28-36/38
  • Molecular Formula: C19H30ClNO
  • Molecular Structure:CAS No:93384-43-1 Botulin A

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  • "Botox Product Name: Botox Synonyms: Onaclostox [USAN]; Botulinum Toxin Type A; AGN 191622; Azzalure; Botox; Botox Cosmetic; Botulin A; Botulin toxin A; Botulinum A neurotoxin; Botulinum neurotoxin type A (EC 3.4.24.69) from clostridium botulinum; Dy...
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References of Botulin A
Title: Botulin Toxins
Synonyms: Botulinum toxins; botulinus toxins
Literature References: Potent neurotoxins produced by Clostridium botulinum. Seven serologically distinct types are known, designated A-G; mol wt ~150 kDa. Zinc-proteases synthesized as non-toxic single-chain precursors which become toxic upon proteolytic cleavage. Active form consists of one heavy and one light chain linked by a disulfide bond. Prevents release of acetylcholine from presynaptic nerve terminals at the neuromuscular junction. Identification of the causative agent of botulism: E. P. Van Ermengem, Z. Hyg. Infektionskrankh. 26, 1 (1897). Isoln: P. T. Snipe, H. Sommer, J. Infect. Dis. 43, 152 (1928). Review of isoln and purification: L. L. Simpson et al., Methods Enzymol. 165, 76-85 (1988); of structure and function: K. Oguma et al., Microbiol. Immunol. 39, 161-168 (1995). Review of pharmacology: J. L. Middlebrook, J. Toxicol. Toxin Rev. 5, 177-190 (1986); of mode of action and detection: M. Wictome, C. C. Shone, J. Appl. Microbiol. Symp. Suppl. 84, 87S-97S (1998). Review of clinical uses in focal dystonias: K. R. Kessler, R. Benecke, Neurotoxicology 18, 761-770 (1997); in cosmetic dermatology: A. Carruthers, J. Carruthers, Basic Clin. Dermatol. 15, 207-236 (1998).
Properties: MLD in mouse: 0.0003 mg/kg (Middlebrook).
Toxicity data: MLD in mouse: 0.0003 mg/kg (Middlebrook)
 
Derivative Type: Botulin A
CAS Registry Number: 93384-43-1
Synonyms: Botulinum toxin type A; oculinum
Manufacturers' Codes: AGN-191622
Trademarks: BoTox (Allergan); Dysport (Ipsen)
Literature References: Clinical trial in blepharospasm: B. Arthurs et al., Can. J. Ophthalmol. 22, 24 (1987); in achalasia: P. J. Pasricha et al., N. Engl. J. Med. 332, 774 (1995); in hyperhidrosis: M. Heckmann et al., ibid. 344, 488 (2001); in spasticity following stroke: A. Brashear et al., ibid. 347, 395 (2002).
 
Derivative Type: Botulin B
CAS Registry Number: 93384-44-2
Synonyms: Botulinum toxin type B
Trademarks: NeuroBloc (Elan)
Literature References: Clinical trial in cervical dystonia: P. A. Cullis et al., Adv. Neurol. 78, 227 (1998).
 
Therap-Cat: Muscle relaxant (skeletal).
Keywords: Muscle Relaxant (Skeletal).