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CAS No 9087-70-1 , Trypsin inhibitor,pancreatic basic

  • Name: Trypsin inhibitor,pancreatic basic
  • Synonyms: Trasylol; Zymofren;Trypsin inhibitor,pancreatic basic; Trazinin; APROTININ; RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA;Iniprol; RP-9921; Bayer A 128; Riker 52G;
  • CAS Registry Number:
  • Water Solubility: Soluble in water
  • Safety Statements: 22-45-36/37-36
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 232-994-9
  • Molecular Weight: 6511.43928
  • InchiKey: ZPNFWUPYTFPOJU-LPYSRVMUSA-N
  • InChI: InChI=1S/C284H432N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-
    282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-
    185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-
    80-161)252(420)346-191(123-208(291)378)246(414)322-149(14)230(398)326-
    168(62-35-39-98-285)234(402)319-146(11)227(395)314-132-215(385)324-181
    (113-141(3)4)247(415)354-199-137-452-453-138-200-263(431)336-179(97-112-
    448-20)242(410)331-176(70-48-107-311-284(304)305)244(412)363-226(154(19)
    372)274(442)358-197(233(401)316-129-212(382)312-130-213(383)318-151(16)
    278(446)447)135-449-451-139-201(355-253(421)186(117-157-57-31-25-32-58-
    157)344-256(424)195(127-220(393)394)350-267(435)204-72-50-109-366(204)
    275(443)167(289)61-43-102-306-279(294)295)265(433)339-182(114-142(5)6)
    248(416)338-180(93-96-218(389)390)276(444)368-111-52-74-206(368)277(445)
    367-110-51-73-205(367)268(436)349-189(122-162-81-89-166(376)90-82-162)
    259(427)362-224(152(17)370)269(437)317-133-216(386)365-108-49-71-203
    (365)266(434)357-202(264(432)333-169(63-36-40-99-286)235(403)320-148(13)
    229(397)328-175(69-47-106-310-283(302)303)243(411)360-223(145(10)22-2)
    272(440)361-222)140-454-450-136-198(325-214(384)131-313-211(381)128-315-
    232(400)183(119-159-75-83-163(373)84-76-159)351-270(438)221(143(7)8)359-
    258(426)190(118-158-59-33-26-34-60-158)352-273(441)225(153(18)371)364-
    245(413)177(335-262(199)430)91-94-207(290)377)261(429)334-172(66-44-103-
    307-280(296)297)236(404)321-147(12)228(396)327-170(64-37-41-100-287)237
    (405)330-173(67-45-104-308-281(298)299)238(406)345-192(124-209(292)379)
    255(423)347-193(125-210(293)380)254(422)343-184(115-155-53-27-23-28-54-
    155)249(417)332-171(65-38-42-101-288)240(408)353-196(134-369)260(428)
    323-150(15)231(399)329-178(92-95-217(387)388)241(409)348-194(126-219
    (391)392)257(425)356-200/h23-34,53-60,75-90,141-154,167-206,221-226,
    369-376H,21-22,35-52,61-74,91-140,285-289H2,1-20H3,(H2,290,377)(H2,291,
    378)(H2,292,379)(H2,293,380)(H,312,382)(H,313,381)(H,314,395)(H,315,
    400)(H,316,401)(H,317,437)(H,318,383)(H,319,402)(H,320,403)(H,321,
    404)(H,322,414)(H,323,428)(H,324,385)(H,325,384)(H,326,398)(H,327,
    396)(H,328,397)(H,329,399)(H,330,405)(H,331,410)(H,332,417)(H,333,
    432)(H,334,429)(H,335,430)(H,336,431)(H,337,439)(H,338,416)(H,339,
    433)(H,340,407)(H,341,419)(H,342,418)(H,343,422)(H,344,424)(H,345,
    406)(H,346,420)(H,347,423)(H,348,409)(H,349,436)(H,350,435)(H,351,
    438)(H,352,441)(H,353,408)(H,354,415)(H,355,421)(H,356,425)(H,357,
    434)(H,358,442)(H,359,426)(H,360,411)(H,361,440)(H,362,427)(H,363,
    412)(H,364,413)(H,387,388)(H,389,390)(H,391,392)(H,393,394)(H,446,
    447)(H4,294,295,306)(H4,296,297,307)(H4,298,299,308)(H4,300,301,309)(H4,
    302,303,310)(H4,304,305,311)/t144-,145-,146-,147-,148-,149-,150-,151-,
    152+,153+,154+,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,
    178-,179-,180-,181-,182-,183-,184-,185-,186-,187-,188-,189-,190-,191-,
    192-,193-,194-,195-,196-,197-,198-,199-,200-,201-,202-,203-,204-,205-,
    206-,221-,222-,223-,224-,225-,226-/m0/s1
  • Risk Statements: R42/43
  • Molecular Formula: C284H432N84O79S7
  • Molecular Structure:CAS No:9087-70-1 Trypsin inhibitor,pancreatic basic

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References of Trypsin inhibitor,pancreatic basic
Title: Aprotinin
CAS Registry Number: 9087-70-1
CAS Name: Pancreatic basic trypsin inhibitor
Synonyms: pancreatic trypsin inhibitor (Kunitz)
Manufacturers' Codes: Bayer A 128; Riker 52G; RP-9921
Trademarks: Antagosan (HMR); Antikrein (Teikoku Zoki); Fosten (Serono); Iniprol (Sanofi Winthrop); Kir Richter (Lepetit); Repulson (Mochida); Trasylol (Bayer); Trazinin (Tobishi); Zymofren (Specia)
Molecular Formula: C284H432N84O79S7
Molecular Weight: 6511.44
Percent Composition: C 52.39%, H 6.69%, N 18.07%, O 19.41%, S 3.45%
Literature References: Serine protease inhibitor which inhibits kallikrein, plasmin, trypsin, chymotrypsin and various intracellular proteases. Single chain polypeptide containing 58 amino acids; found in tissues and blood, highest concentration in bovine parotid gland, pancreas and lung. Initial description: H. Kraut et al., Z. Physiol. Chem. 192, 1 (1930). Isoln from bovine pancreas: M. Kunitz, J. H. Northrup, J. Gen. Physiol. 19, 991 (1936); from bovine parotid glands: H. Kraut, R. K?rbel, US 2890986 (1959 to Bayer). Amino acid sequence: B. Kassell et al., Biochem. Biophys. Res. Commun. 18, 255 (1965); F. A. Anderer, S. H?rnle, Z. Naturforsch. 20b, 457, 462 (1965); B. Kassell, M. Laskowski, Biochem. Biophys. Res. Commun. 20, 463 (1966). Two-dimensional 1H-NMR studies: K. Nagayama, K. Wüthrich, Eur. J. Biochem. 114, 365 (1981); G. Wagner et al., ibid. 375. Review of early literature: I. Trautschold et al., Biochem. Pharmacol. 16, 59-72 (1957). Review of mechanism of therapeutic action: G. Haberland, R. McConn, Fed. Proc. 38, 2760-2767 (1979). Review of use as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones: E. S. Zyzner, Life Sci. 28, 1861-1866 (1981). Review of biochemistry and applications: H. Fritz, G. Wunderer, Arzneim.-Forsch. 33, 479-494 (1983); of pharmacology and therapeutic efficacy in reducing blood loss associated with cardiac surgery: R. Davis, R. Whittington, Drugs 49, 954-983 (1995).
Properties: uv max (pH 5.9): 280 nm. Isoelec pt pH 10.5. Stable in neutral or acid media at high temp. Irreversible changes in molecular structure occur in strongly alkaline media (pH >12). Partially and reversibly denatured on treatment with 8M urea. May be kept at room temp in physiological saline soln for >1 yr without detrimental effects. LD50 i.v. in mice: 2500000 kallikrein inhibitor units/kg (Trautschold).
Absorption maximum: uv max (pH 5.9): 280 nm
Toxicity data: LD50 i.v. in mice: 2500000 kallikrein inhibitor units/kg (Trautschold)
Use: Proteolytic inhibitor in radioimmunoassays of polypeptide hormones.
Therap-Cat: Protease inhibitor.
Keywords: Protease Inhibitor.