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CAS No 9063-57-4 , L-Arginine,L-threonyl-L-lysyl-L-prolyl-

  • Name: L-Arginine,L-threonyl-L-lysyl-L-prolyl-
  • Synonyms: 100: PN: US20060127404 SEQID: 100claimed sequence;Taftsin; 56: PN: WO0183525 TABLE: 4 claimed protein; 67: PN: WO2004002424 SEQID: 100 claimed protein; 1: PN: US20040132667 SEQID: 1unclaimed protein; Taphcin; 32: PN: WO2009105671SEQID: 32 unclaimed protein; Tafcine; 7: PN: WO02055543SEQID: 12 unclaimed protein; 29: PN:US6720141 SEQID: 26 unclaimed protein; 60: PN: WO2007124090 SEQID: 60 claimedsequence; 50: PN: WO03084477 PAGE: 24 claimed protein; 229: PN: WO0024782 SEQID: 263 claimed protein; 52: PN: WO2007047969 SEQID: 52unclaimed sequence; 27: PN: WO2009126037 PAGE: 5 unclaimed sequence;L-Arginine,L-threonyl-L-lysyl-L-prolyl-; Tuftsin; 14: PN:WO2007076032 TABLE: 59 unclaimed sequence; 14: PN: US20030226155 SEQID: 14 unclaimed protein; 52:PN: US20070031440 SEQID: 14 unclaimed sequence;L-Arginine,N2-[1-(N2-L-threonyl-L-lysyl)-L-prolyl]-; 60: PN:US20090258017 SEQID: 60 claimed protein; 253: PN:WO0069900 SEQID: 1558 unclaimed protein; 30: PN: WO2006010057 SEQID: 60 unclaimed protein; 137: PN: US20030119021 SEQID: 137unclaimed protein; 1271: PN:US20090175821 SEQID: 1558 claimed protein; 11: PN: WO2004002417 SEQID: 100 claimed protein; 258: PN: WO0069900 SEQID: 1563unclaimed protein; 2: PN: WO2009033726 PAGE: 99 claimedprotein; L-Threonyl-L-lysyl-L-prolyl-L-arginine;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.48g/cm3
  • Flash Point: °C
  • Molecular Weight: 500.59
  • InChI: InChI=1S/C21H40N8O6/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26)
  • Molecular Formula: C21H40 N8 O6
  • Molecular Structure:CAS No:9063-57-4 L-Arginine,L-threonyl-L-lysyl-L-prolyl-

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9063-57-4 TUFTSIN

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9063-57-4 H-5035.0050 H-THR-LYS-PRO-ARG-OH

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References of L-Arginine,L-threonyl-L-lysyl-L-prolyl-
Title: Tuftsin
CAS Registry Number: 9063-57-4
CAS Name: L-Threonyl-L-lysyl-L-prolyl-L-arginine
Synonyms: N2-[1-(N2-L-threonyl-L-lysyl)-L-prolyl]-L-arginine
Molecular Formula: C21H40N8O6
Molecular Weight: 500.59
Percent Composition: C 50.39%, H 8.05%, N 22.38%, O 19.18%
Literature References: A naturally occurring tetrapeptide having a variety of immunopotentiating properties, especially stimulation and enhancement of phagocytosis. It also exhibits antitumor and antibacterial activity and has been shown to possess chemotactic, migration-enhancing, and mitogenic properties for leukocytes. Discovered during research on the physiological role of cytophilic gamma-globulin: V. A. Najjar, K. Nishioka, Nature 228, 672 (1970). Produced in the spleen; present in mammalian blood in the gamma globulin fraction as part of the larger molecule leucokinin. Isoln and characterization: K. Nishioka et al., Biochim. Biophys. Acta 310, 217 (1973); V. A. Najjar, US 3778426 (1973 to Research Corp.). Solid phase synthesis: K. Nishioka et al., Biochem. Biophys. Res. Commun. 47, 172 (1972); eidem, Biochim. Biophys. Acta 310, 230 (1973). Synthesis by fragment condensation: J. Vicar et al., Collect. Czech. Chem. Commun. 41, 3467 (1976); by liquid phase method: S. Nozaki et al., Bull. Chem. Soc. Jpn. 50, 422 (1977). 13C-NMR and circular dichroism studies: I. Z. Siemion et al., Eur. J. Biochem. 112, 339 (1980). Conformational studies have provided conflicting evidence on the structure, cf. M. Blumenstein et al., Biochemistry 18, 4247 (1979). Specific receptors on macrophages, monocytes, and granulocytes are thought to mediate the biological activity of tuftsin: A. Constantopoulos, V. A. Najjar, J. Biol. Chem. 248, 3819 (1973); R. M. G. Nair et al., Immunochemistry 15, 901 (1978); Z. Bar-Shavit et al., Biochem. Biophys. Res. Commun. 94, 1445 (1980). Its physiological significance has been shown in patients in whom tuftsin deficiency has resulted in a human syndrome with increased incidence of severe infections: Macrophages and Lymphocytes, Part A, M. R. Escobar, H. Friedman, Eds. (Plenum Press, New York, 1980) pp 131-147; Lymphokine Reports, E. Pick, Ed. (Academic Press, New York, 1980) pp 157-159; V. A. Najjar, Med. Biol. 59, 134 (1981). General biological properties: V. A. Najjar, Mol. Cell. Biochem. 41, 1 (1981). Antitumor activity: K. Nishioka et al., ibid. 13. Bactericidal activity: J. Martinez, F. Winternitz, ibid. 123. Analogs: F. Z. Siemion, ibid. 99. Reviews: V. A. Najjar, Exp. Cell Biol. 46, 114-126 (1978); eidem, Adv. Exp. Med. Biol. 121A, 131-147 (1980); K. Nishioka et al., Life Sci. 28, 1081-1090 (1981); V. A. Najjar, Mol. Cell. Biochem. 41, 73-98 (1981). Conference proceedings: Ann. N.Y. Acad. Sci. 419, entitled "Antineoplastic, Immunogenic and Other Effects of the Tetrapeptide Tuftsin: a Natural Macrophage Activator", V. A. Najjar, M. Fridkin, Eds. (1983) pp 1-273.