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CAS No 62087-72-3 , L-Arginine, L-a-aspartyl-L-seryl-L-a-aspartyl-L-prolyl-

  • Name: L-Arginine, L-a-aspartyl-L-seryl-L-a-aspartyl-L-prolyl-
  • Synonyms: Pentapeptide DSDPR; 18: PN:US20030226155 SEQID: 18 unclaimed sequence; HEPP;Pentyde; 2151: PN: WO03060071 SEQID: 2213unclaimed;L-Arginine,N2-[1-[N-(N-L-a-aspartyl-L-seryl)-L-a-aspartyl]-L-prolyl]-; Pentigetide; IgE pentapeptide; 56: PN: US20070031440 SEQID: 18 unclaimed sequence; Hamburgerpeptide;L-Aspartyl-L-seryl-L-aspartyl-L-prolyl-L-arginine;L-Arginine, L-a-aspartyl-L-seryl-L-a-aspartyl-L-prolyl-; Human IgE pentapeptide;
  • CAS Registry Number:
  • Density: 1.69g/cm3
  • Refractive index: 1.688
  • Molecular Weight: 588.57
  • InChI: InChI=1/C22H36N8O11/c23-10(7-15(32)33)17(36)29-13(9-31)18(37)28-12(8-16(34)35)20(39)30-6-2-4-14(30)19(38)27-11(21(40)41)3-1-5-26-22(24)25/h10-14,31H,1-9,23H2,(H,27,38)(H,28,37)(H,29,36)(H,32,33)(H,34,35)(H,40,41)(H4,24,25,26)
  • Molecular Formula: C22H36 N8 O11
  • Molecular Structure:CAS No:62087-72-3 L-Arginine, L-a-aspartyl-L-seryl-L-a-aspartyl-L-prolyl-

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References of L-Arginine, L-a-aspartyl-L-seryl-L-a-aspartyl-L-prolyl-
Title: Pentigetide
CAS Registry Number: 62087-72-3
CAS Name: N2-[1-[N-(N-L-a-Aspartyl-L-seryl)-L-a-aspartyl]-L-prolyl]-L-arginine
Synonyms: human IgE pentapeptide; HEPP
Trademarks: Pentyde (Immunetech)
Molecular Formula: C22H36N8O11
Molecular Weight: 588.57
Percent Composition: C 44.89%, H 6.17%, N 19.04%, O 29.90%
Literature References: Synthetic pentapeptide with antiallergic activity. Structure corresponds to amino acids 320-324 of the epsilon chain of human immunoglobulin E (IgE). Prepn: R. N. Hamburger, DE 2602443; idem, US 4171299 (1976, 1979 both to Univ. California). Inhibition of IgE-mediated immediate hypersensitivity response: idem, Science 189, 389 (1975). Stimulation of peritoneal macrophages: E. Tzehoval et al., Proc. Natl. Acad. Sci. USA 75, 3400 (1978). Mechanism of action study: R. N. Hamburger, Immunology 38, 781 (1979). Clinical evaluations in allergic rhinitis: G. A. Cohen et al., Ann. Allergy 52, 83 (1984); B. M. Prenner, ibid. 58, 332 (1987).
Properties: [a]D20 -78.6° (c = 1 in water).
Optical Rotation: [a]D20 -78.6° (c = 1 in water)
Therap-Cat: Antiallergic.
Keywords: Antiallergic.