Home > Name List By n > N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl] pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl...

CAS No 9034-40-6 , N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]
pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-
methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-
oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-
yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-
oxopyrrolidine-2-carboxamide

  • Name: N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]
    pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-
    methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-
    oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-
    yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-
    oxopyrrolidine-2-carboxamide
  • Synonyms: N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]
    pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-
    methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-
    oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-
    yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-
    oxopyrrolidine-2-carboxamide; Hypocrine; Lutamin; Luforan; Fertagyl; Factrel; Lutal; Relefact; GONADORELIN;Dirigestran; Lutrefact;
  • CAS Registry Number:
  • Density: 1.54 g/cm3
  • Safety Statements: An experimental teratogen. Human reproductive effects in women by subcutaneous route: menstrual cycle changes and other unspecified effects. Experimental reproductive effects. Used in the treatment of oligospermia and male infertility. See also LUTEINIZING HORMONE and LUTEINIZING HORMONE-RELEASING HORMONE, DIACETATE (SALT); LUTEINIZING HORMONE-RELEASING HORMONE, DIACETATE, TETRAHYDRATE; LUTEINIZING HORMONE-RELEASING HORMONE (PIG), 6-(O-(1,1-DIMETHYLETHYL)-d-SERINE)-9-(N-ETHYL-l-PROLINAMIDE)-10-DEGLYCINAMIDE-.
  • EINECS: 232-895-0
  • Molecular Weight: 1182.2901
  • InchiKey: XLXSAKCOAKORKW-UHFFFAOYSA-N
  • InChI: InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54
    (85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-
    11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-
    7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-
    36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,
    1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,
    80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)
  • Molecular Formula: C55H75N17O13
  • Molecular Structure:CAS No:9034-40-6 N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]<br />pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-<br />methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-<br />oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-<br />yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-<br />oxopyrrolidine-2-carboxamide

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9034-40-6 GONADORELIN

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
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9034-40-6 LUTEINIZING HORMONE

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9034-40-6 Luteinizinghormone-releasing factor

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References of N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]
pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-
methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-
oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-
yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-
oxopyrrolidine-2-carboxamide
Title: LH-RH
CAS Registry Number: 9034-40-6
CAS Name: Luteinizing hormone-releasing factor
Synonyms: LH-RF; luteinizing hormone-releasing hormone; LRF; LRH; gonadorelin; gonadotropin-releasing factor; gonadoliberin; luliberin; LH-RH/FSH-RH
Trademarks: Fertagyl (Intervet); Fertiral (HMR); Kryptocur (HMR); Relefact LH-RH (HMR)
Molecular Formula: C55H75N17O13
Molecular Weight: 1182.29
Percent Composition: C 55.87%, H 6.39%, N 20.14%, O 17.59%
Literature References: Neurohumoral hormone produced in the hypothalamus which stimulates the secretion of the pituitary hormones, LH (luteinizing hormone) and FSH (follicle-stimulating hormone) q.q.v., which in turn produce changes resulting in the induction of ovulation. Isoln from porcine hypothalamic extracts: A. V. Schally et al., Biochem. Biophys. Res. Commun. 43, 393 (1971). Structure: Matsuo et al., ibid. 1334; Baba et al., ibid. 44, 459 (1971); Burgus et al., C.R. Seances Acad. Sci. Ser. D 273, 1611 (1971). Solid phase synthesis: Monahan et al., ibid. 508; Monahan, Rivier, Biochem. Biophys. Res. Commun. 48, 1100 (1972); Coy et al., Methods Enzymol. 37, 416 (1975); D. H. Rich, S. K. Gurwara, Tetrahedron Lett. 1975, 301. Industrial prepn: Geiger et al., DE 2213737 (1973 to Hoechst). Confirmation of biological activity: A. V. Schally et al., Science 173, 1036 (1971). Pharmacokinetics: T. W. Redding, J. Clin. Endocrinol. Metab. 37, 626 (1973). Reviews of physiology and implications in fertility control: A. V. Schally et al., Fertil. Steril. 22, 703 (1971); R. Guillemin, Contraception 6, 1 (1972). Review of LH-RH and other hypothalamic hormones: A. V. Schally et al., Science 179, 341 (1973); A. V. Schally, ibid. 202, 18-28 (1978); of LH-RH and somatostatin, q.v.: S. M. McCann, Annu. Rev. Pharmacol. Toxicol. 22, 491-515 (1982). General reviews: J. Sandow, Clin. Endocrinol. 18, 571-592 (1983); S. M. McCann, J. Endocrinol. Invest. 6, 243-251 (1983).
Properties: [a]D25 -50° (1% acetic acid). Chymotrypsin, papain, subtilisin, thermolysin destroy the pituitary hormone releasing action of LH-RH.
Optical Rotation: [a]D25 -50° (1% acetic acid)
 
Derivative Type: Acetate (salt) hydrate
Synonyms: Gonadorelin acetate
Trademarks: Cystorelin (Abbott); Hypocrine (Tanabe Seiyaku); Lutrelef (Ferring); Lutrepulse (Ortho)
Literature References: C55H75N17O13.xC2H4O2.yH2O, as the diacetate tetrahydrate or a mixture of monoacetate and diacetate hydrates.
 
Derivative Type: Hydrochloride
CAS Registry Number: 51952-41-1
Manufacturers' Codes: AY-24031
Trademarks: HRF (Ayerst); Factrel (Ayerst)
 
Therap-Cat: Gonad-stimulating principle.
Therap-Cat-Vet: Gonad-stimulating principle.
Keywords: Gonad-Stimulating Principle.