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CAS No 9002-04-4 , Thrombin

  • Name: Thrombin
  • Synonyms: Thrombin; Thrombin, Human Plasma; Thrombin, Plasminogen-Free, Bovine; thrombin time;thrombin from bovine plasma; thrombin from human plasma; Thrombin, Citrate-Free, HumanPlasma; Thrombin, Bovine;
  • CAS Registry Number:
  • Melting Point: 166-168 deg C
  • Boiling Point: 290-295 deg C @ 3.5 mm Hg
  • Safety Statements: A poison by intravenous route. Low toxicity by skin contact. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating vapors.
  • Hazard Symbols: Xn: Harmful;
  • HS Code: 30021099
  • EINECS: 232-648-7
  • Molecular Weight: 0
  • InChI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
  • Risk Statements: 36/37/38-42
  • Molecular Formula: C6H14O6
  • Molecular Structure:CAS No:9002-04-4 Thrombin

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References of Thrombin
Title: Thrombin
CAS Registry Number: 9002-04-4
Synonyms: Blood-coagulation factor IIa; factor IIa; fibrinogenase; EC 3.4.21.5
Literature References: Multifunctional serine protease generated at the site of vascular injury from prothrombin, q.v. Key enzyme in the coagulation cascade; converts fibrinogen into fibrin and activates factor XIII, q.v., which cross-links and stabilizes the fibrin polymer. Enhances inflammation and tissue repair via receptor-mediated cellular responses; activates platelets and endothelial cells and stimulates proliferation of fibroblasts and smooth muscle cells. The mature enzyme is glycosylated and consists of two polypeptide chains, designated A and B, covalently linked by a disulfide bridge. Exists in several forms, the largest and most active being the 39 kDa a-thrombin. The human a-thrombin A chain contains 36 amino acids; the B chain contains 259 residues. Purification by conversion from bovine prothrombin: W. H. Seegers et al., J. Biol. Chem. 126, 91 (1938); W. H. Seegers, D. A. McGinty ibid. 146, 511 (1942); H. P. Smith, US 2398077 (1946 to Parke, Davis). Sequence of bovine A chain: S. Magnussen, Biochem. J. 110, 25P (1968). Primary structure of human a-thrombin: R. J. Butkowski et al., J. Biol. Chem. 252, 4942 (1977). Review of structure: M. T. Stubbs, W. Bode, Thromb. Res. 69, 1-58 (1993). Review of cloning, structure and function of thrombin receptors: S. R. Coughlin et al., Cold Spring Harbor Symp. Quant. Biol. 57, 149-154 (1992); C. Tapparelli et al., Trends Pharmacol. Sci. 14, 426-428 (1993). Review of role in hemostasis: J. W. Fenton et al., Hematol. Oncol. Clin. North Am. 7, 1107-1119 (1993); in cell adhesion and proliferation: R. Bar-Shavit et al., Am. J. Resp. Cell Mol. 6, 123-130 (1992); in inflammation and healing and effects in RA: R. Morris et al., Ann. Rheum. Dis. 53, 72-79 (1994).
 
Derivative Type: Topical thrombin
Trademarks: Thrombinar (King); Thrombogen (J & J); Thrombostat (Pfizer)
Literature References: A standardized prepn of bovine thrombin. Review of clinical experience: R. T. Tidrick et al., Surgery 14, 191-196 (1943); in combination with fibrin: M. Brennan, Blood Rev. 5, 240-244 (1991).
Properties: White powder. Sol in water, isotonic saline.
 
Therap-Cat: Hemostatic (local).
Keywords: Hemostatic.