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CAS No 9002-01-1 , 4-cyclohexylpyrrolidine-2-carboxylic acid

  • Name: 4-cyclohexylpyrrolidine-2-carboxylic acid
  • Synonyms: 9002-01-1;4-cyclohexylpyrrolidine-2-carboxylic acid; L-Proline,4-cyclohexyl-; SureCN197230;ACMC-20airn; (4S)-; AKOS015962191; CTK8G4672; 4-cyclohexylpyrrolidine-2-carboxylic Acid;
  • CAS Registry Number:
  • Flash Point: 161.8°C
  • Boiling Point: 343.9°Cat760mmHg
  • Density: 1.113g/cm3
  • Refractive index: 1.517
  • Safety Statements: Moderately toxic by intravenous route. Human systemic effects by subcutaneous or intravenous routes: effects on the nose, dyspnea and unspecified allergic affects. A thrombolytic agent used to dissolve blood clots in vivo.
  • Hazard Symbols: B,Xi
  • Flash Point: 161.8°C
  • EINECS: 232-647-1
  • Molecular Weight: 197.27406
  • InchiKey: XRZWVSXEDRYQGC-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,
    1-7H2,(H,13,14)
  • Risk Statements: 36/37/38
  • Molecular Formula: C11H19NO2
  • Molecular Structure:CAS No:9002-01-1 4-cyclohexylpyrrolidine-2-carboxylic acid

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References of 4-cyclohexylpyrrolidine-2-carboxylic acid
Title: Streptokinase
CAS Registry Number: 9002-01-1
Synonyms: Streptococcal fibrinolysin; plasminokinase
Trademarks: Kabikinase (Pharmacia); Streptase (ZLB Behring)
Literature References: Single-chain protein produced by b-hemolytic streptococci; mol wt ~47 kDa. Activates plasminogen to produce plasmin which dissolves fibrin. Discovery: W. S. Tillet, R. L. Garner, J. Exp. Med. 58, 485 (1933). Isoln from streptococcal culture filtrates: L. R. Christensen, J. Gen. Physiol. 28, 363 (1945). Purification: M. Siegel et al., US 3042586 (1962 to Merck & Co.); P. K. Siiteri, R. D. Mills, US 3226304 (1965 to Am. Cyanamid); and characterization: E. C. De Renzo et al., J. Biol. Chem. 242, 533 (1967). Review of isoln, assay and properties: F. B. Taylor, R. H. Tomar, Methods Enzymol. 19, 807-821 (1970); F. Castellino, Jr. et al., ibid. 45B, 244-257 (1976); of mechanism of action: K. N. N. Reddy in Fibrinolysis, D. L. Kline, K. N. N. Reddy, Eds. (CRC, Boca Raton, 1980) pp 71-94. Clinical trials in acute myocardial infarction: J. L. Anderson et al., N. Engl. J. Med. 308, 1312 (1983); ISIS-2 Collaborative Group, Lancet 2, 349 (1988). Clinical comparison with alteplase (tPA): GISSI-2 and Int. Study Group, Eur. Heart J. 13, 1692 (1992). Pharmacokinetics: D. S. Grierson, T. D. Bjornsson, Clin. Pharmacol. Ther. 41, 304 (1987). Review of clinical efficacy in deep venous thrombosis: L. Q. Rogers, C. L. Lutcher, Am. J. Med. 88, 389-395 (1990); in myocardial infarction: K. L. Goa et al., Drugs 39, 693-719 (1990); P. E. Battershill et al., Drugs Aging 4, 63-86 (1994).
Therap-Cat: Thrombolytic.
Keywords: Thrombolytic.