Home > Name List By 1 > 1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5, 6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperi...

CAS No 89419-40-9 , 1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,
6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one

  • Name: 1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,
    6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one
  • Synonyms: Mosapramine [INN]; Mosapramine (INN);89419-40-9;1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,
    6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one; NCGC00183853-01;
  • CAS Registry Number:
  • Flash Point: 365.2°C
  • Boiling Point: 680.2°C at 760 mmHg
  • Density: 1.29g/cm3
  • Refractive index: 1.666
  • Flash Point: 365.2°C
  • Molecular Weight: 479.0567
  • InchiKey: PXUIZULXJVRBPC-UHFFFAOYSA-N
  • InChI: InChI=1S/C28H35ClN4O/c29-23-12-11-22-10-9-21-6-1-2-7-24(21)32(25(22)20-
    23)16-5-15-31-18-13-28(14-19-31)27(34)30-26-8-3-4-17-33(26)28/h1-2,6-7,
    11-12,20,26H,3-5,8-10,13-19H2,(H,30,34)
  • Molecular Formula: C28H35ClN4O
  • Molecular Structure:CAS No:89419-40-9 1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,<br />6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one

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89419-40-9 Mosapramine

  • United States LGM Pharma [Manufacturer]
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89419-40-9 MOSAPRAMINE

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References of 1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,
6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one
Title: Mosapramine
CAS Registry Number: 89419-40-9
CAS Name: 1￠-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydrospiro[imidazo[1,2-a]pyridine-3(2H),4￠-piperidin]-2-one
Synonyms: 1￠-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-1,2,3,5,6,7,8,8a-octahydro-2-oxoimidazo[1,2-a]-pyridine-3-spiro-4￠-piperidine; 3-chloro-5-[3-(2-oxo-1,2,3,5,6,7,8,8a-octahydroimidazo[1,2-a]-pyridine-3-spiro-4￠-piperidino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine; clospipramine
Molecular Formula: C28H35ClN4O
Molecular Weight: 479.06
Percent Composition: C 70.20%, H 7.36%, Cl 7.40%, N 11.70%, O 3.34%
Literature References: Dopamine receptor antagonist with adrenoceptor blocking activity; metabolite of clocapramine, q.v. Prepn: C. Tashiro, I. Horii, US 4337260 (1982 to Yoshitomi); C. Tashiro et al., Yakugaku Zasshi 109, 93 (1989), C.A. 112, 35749j (1990). X-ray crystallographic analysis: I. Ueda, C. Tashiro, Acta Crystallogr. C40, 422 (1984). Receptor binding studies: M. Setoguchi et al., Eur. J. Pharmacol. 112, 313 (1985). Pharmacokinetics and metabolism: J. Ishigooka et al., Psychopharmacology 97, 303 (1989). Toxicity data: H. Horizoe et al., Oyo Yakuri 37, 529 (1989); C.A. 111, 167174g (1989). HPLC determn in plasma: K. Hikida et al., Anal. Sci. 6, 367 (1990).
 
Derivative Type: Dihydrochloride
CAS Registry Number: 98043-60-8
Manufacturers' Codes: Y-516
Trademarks: Cremin (Yoshitomi)
Molecular Formula: C28H35ClN4O.2HCl
Molecular Weight: 551.98
Percent Composition: C 60.93%, H 6.76%, Cl 19.27%, N 10.15%, O 2.90%
Properties: White crystals, mp 271°. LD50 in male and female mice (mg/kg): 1008, 1293 orally; 74, 116 i.p.; 1147, 1264 s.c. (Horizoe).
Melting point: mp 271°
Toxicity data: LD50 in male and female mice (mg/kg): 1008, 1293 orally; 74, 116 i.p.; 1147, 1264 s.c. (Horizoe)
 
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Other Tricyclics; Dopamine Receptor Antagonist.