Home > Name List By 1 > 1-(4-chlorophenyl)-2-[3-(5, 6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone

CAS No 23047-25-8 , 1-(4-chlorophenyl)-2-[3-(5,
6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone

  • Name: 1-(4-chlorophenyl)-2-[3-(5,
    6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone
  • Synonyms: Lopramine; Lofepramina [INN-Spanish]; CHEBI:47782; 23047-25-8;1-(4-chlorophenyl)-2-[3-(5,
    6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone; Lofepraminum [INN-Latin]; Gamonil; Lofepramine [INN:BAN]; Amplit;
  • CAS Registry Number:
  • Flash Point: 301.6°C
  • Boiling Point: 575°Cat760mmHg
  • Density: 1.173g/cm3
  • Refractive index: 1.607
  • Flash Point: 301.6°C
  • EINECS: 245-396-8
  • Molecular Weight: 418.95838
  • InchiKey: SAPNXPWPAUFAJU-UHFFFAOYSA-N
  • InChI: InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-
    24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,
    17-19H2,1H3
  • Molecular Formula: C26H27ClN2O
  • Molecular Structure:CAS No:23047-25-8 1-(4-chlorophenyl)-2-[3-(5,<br />6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone

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23047-25-8 Lofepramine

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23047-25-8 Lofepramine

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23047-25-8 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]ethanone

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References of 1-(4-chlorophenyl)-2-[3-(5,
6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone
Title: Lofepramine
CAS Registry Number: 23047-25-8
CAS Name: 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]ethanone
Synonyms: 4￠-chloro-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]acetophenone; N-methyl-N-(4-chlorobenzoylmethyl)-3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propylamine; lopramine
Molecular Formula: C26H27ClN2O
Molecular Weight: 418.96
Percent Composition: C 74.54%, H 6.50%, Cl 8.46%, N 6.69%, O 3.82%
Literature References: Psychotropic drug related to imipramine, q.v. Prepn: E. Eriksoo et al., GB 1177525; eidem, US 3637660 (1970, 1972 both to AB Leo). Chemistry and pharmacology: E. Eriksoo, O. Rohte, Arzneim.-Forsch. 20, 1561 (1970). Absorption and metabolism: J. R. Tulic et al., Acta Pharmacol. Toxicol. 32, 304 (1973). Distribution and excretion: G. Plym Forshell, Xenobiotica 5, 73 (1975). Pharmacokinetics: G. Plym Forshell et al., Eur. J. Clin. Pharmacol. 9, 291 (1976). Clinical study: S. Wright, L. Herrmann, Arzneim.-Forsch. 26, 1167 (1976).
Properties: Crystals from methanol or acetone, mp 104-106°. Easily oxidized by air and other oxidizing agents to desipramine and p-chlorobenzoic acid.
Melting point: mp 104-106°
 
Derivative Type: Hydrochloride
CAS Registry Number: 26786-32-3
Manufacturers' Codes: Leo 640
Trademarks: Amplit (Daiichi); Gamanil (Merck KGaA); Gamonil (Merck KGaA); Timelit (UCB); Tymelyt (Lundbeck)
Molecular Formula: C26H27ClN2O.HCl
Molecular Weight: 455.42
Percent Composition: C 68.57%, H 6.20%, Cl 15.57%, N 6.15%, O 3.51%
Properties: Crystals from butanone, mp 152-154°. Sol in methanol, ethanol, chloroform. Practically insol in water. LD50 in mice, rats (mg/kg): >2500, >1000 orally; 920, >1000 i.p.; >1000, >1000 s.c. (Eriksoo, Rohte).
Melting point: mp 152-154°
Toxicity data: LD50 in mice, rats (mg/kg): >2500, >1000 orally; 920, >1000 i.p.; >1000, >1000 s.c. (Eriksoo, Rohte)
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.