Home > Name List By 5 > 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

CAS No 89226-50-6 , 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

  • Name: 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl
    2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Synonyms: Iperten; Artedil; 120092-68-4; 89226-50-6;5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl
    2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Franidipine;Manidipine 6300;
  • CAS Registry Number:
  • Density: 1.232 g/cm3
  • Molecular Weight: 610.69942
  • InchiKey: ANEBWFXPVPTEET-UHFFFAOYSA-N
  • InChI: InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)
    43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-
    26)27-13-8-5-9-14-27/h4-16,23,32-33,36H,17-22H2,1-3H3
  • Molecular Formula: C35H38N4O6
  • Molecular Structure:CAS No:89226-50-6 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl<br />2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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References of 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Title: Manidipine
CAS Registry Number: 89226-50-6
CAS Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester
Synonyms: 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl (±)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinecarboxylate; franidipine
Molecular Formula: C35H38N4O6
Molecular Weight: 610.70
Percent Composition: C 68.83%, H 6.27%, N 9.17%, O 15.72%
Literature References: Dihydropyridine calcium channel blocker. Prepn: K. Meguro, A. Nagaoka, EP 94159; eidem, US 4892875 (1983, 1990, both to Takeda); K. Meguro et al., Chem. Pharm. Bull. 33, 3787 (1985). Synthesis and bioactivity of optical isomers: M. Kajino et al., ibid. 37, 2225 (1989). Acute toxicity study: S. Chiba et al., Yakuri to Chiryo 17, Suppl. 4, 961 (1989), C.A. 111, 146499b (1989). Determn of enantiomers in human serum: M. Yamaguchi et al., J. Chromatogr. 575, 123 (1992). Clinical evaluation in hypertension: K. Mizuno et al., Curr. Ther. Res. 52, 248 (1992).
Properties: Light yellow crystals from isopropyl ether + hexane, mp 125-128°.
Melting point: mp 125-128°
 
Derivative Type: Dihydrochloride
CAS Registry Number: 89226-75-5
Manufacturers' Codes: CV-4093
Trademarks: Calslot (Takeda)
Molecular Formula: C35H38N4O6.2HCl
Molecular Weight: 683.62
Percent Composition: C 61.49%, H 5.90%, N 8.20%, O 14.04%, Cl 10.37%
Properties: Two crystalline forms. a-form: yellow crystals, mp 157-163°. b-form: light yellow, fine crystals, mp 174-180°. Also prepd as the monohydrate, mp 167-170°. LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba).
Melting point: mp 157-163°; mp 174-180°; mp 167-170°
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba)
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Dihydropyridine Derivatives; Calcium Channel Blocker; Dihydropyridine Derivatives.