Home > Name List By n > N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide

CAS No 88069-67-4 , N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide

  • Name: N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide
  • Synonyms: Pilsicainida [INN-Spanish]; Pilsicainide [INN]; Pilsicainide (INN);Pilzicainide;N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide; pilsicainide hydrochloride; Pilsicainidum [INN-Latin];
  • CAS Registry Number:
  • Melting Point: 272.385
  • Density: 1.11 g/cm3
  • Refractive index: 1.581
  • Molecular Weight: 272.38526
  • InchiKey: BCQTVJKBTWGHCX-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H24N2O/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)
    11-5-9-17/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20)
  • Molecular Formula: C17H24N2O
  • Molecular Structure:CAS No:88069-67-4 N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide

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References of N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide
Title: Pilsicainide
CAS Registry Number: 88069-67-4
CAS Name: N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide
Synonyms: tetrahydro-1H-pyrrolizine-7a(5H)-aceto-2￠,6￠-xylidide; N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide
Molecular Formula: C17H24N2O
Molecular Weight: 272.39
Percent Composition: C 74.96%, H 8.88%, N 10.28%, O 5.87%
Literature References: Structural analog of lidocaine, q.v. Prepn: S. Miyano et al., EP 89061; eidem, US 4564624 (1983, 1986 both to Suntory); eidem, J. Med. Chem. 28, 714 (1985). Pharmacology: K. Aisaka et al., Arzneim.-Forsch. 35, 1239 (1985); T. Hidaka et al., ibid. 1381. Clinical evaluation in supraventricular tachycardia: T. Terazawa et al., Am. Heart J. 121, 1437 (1991).
 
Derivative Type: Hydrochloride hemihydrate
CAS Registry Number: 88069-49-2
Manufacturers' Codes: SUN-1165
Trademarks: Sunrythm (Suntory)
Molecular Formula: C17H24N2O.HCl.?H2O
Molecular Weight: 317.85
Percent Composition: C 64.24%, H 8.24%, N 8.81%, O 7.55%, Cl 11.15%
Properties: Crystals from ethanol-ether, mp 212-214°. LD50 in mice (mg/kg): 410 s.c. (Miyano, 1985).
Melting point: mp 212-214°
Toxicity data: LD50 in mice (mg/kg): 410 s.c. (Miyano, 1985)
 
Therap-Cat: Antiarrhythmic.
Keywords: Antiarrhythmic.