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CAS No 87760-53-0 , Tandospirone

  • Name: Tandospirone
  • Synonyms: NCGC00182990-01; Tandospirone (INN); DSSTox_RID_83031; SureCN49026;87760-53-0; AC1L3LQY;Tandospirone; Tandospirone [INN:BAN]; DSSTox_CID_28762;
  • CAS Registry Number:
  • Density: 1.239g/cm3
  • Refractive index: 1.589
  • Molecular Weight: 383.48726
  • InchiKey: CEIJFEGBUDEYSX-FZDBZEDMSA-N
  • InChI: InChI=1S/C21H29N5O2/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-
    24-10-12-25(13-11-24)21-22-6-3-7-23-21/h3,6-7,15-18H,1-2,4-5,
    8-14H2/t15-,16+,17+,18-
  • Molecular Formula: C21H29N5O2
  • Molecular Structure:CAS No:87760-53-0 Tandospirone

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87760-53-0 Tandospirone

  • United States LGM Pharma [Manufacturer]
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  • Address: 922 Clint Moore Road
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87760-53-0 TANDOSPIRONE

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
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  • Switzerland BIOTREND Chemicals AG [Manufacturer]
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87760-53-0 Tandospirone

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87760-53-0 Tandospirone Citrate

  • As a selective 5-HT1A agonist Tandospirone Citrate shows an clinical effect on antianxiety and psychosomatic disease, and is now used for many kinds of neurosis derived anxiety, as generalized anxiety, essential hypertension and peptic ulcer. Tandosp...
  • China Sichuan Credit Chemwerth Pharmaceutical Co., Ltd [Manufacturers]
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87760-53-0 TANDOSPIRONE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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References of Tandospirone
Title: Tandospirone
CAS Registry Number: 87760-53-0
CAS Name: (3aa,4b,7b,7aa)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione
Synonyms: (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3-bicyclo[2.2.1]heptanedicarboximide
Molecular Formula: C21H29N5O2
Molecular Weight: 383.49
Percent Composition: C 65.77%, H 7.62%, N 18.26%, O 8.34%
Literature References: Serotonin (5-HT1A) receptor agonist. Prepn: K. Ishizumi et al., EP 82402; eidem, US 4507303 (1983, 1985 both to Sumitomo); idem et al., Chem. Pharm. Bull. 39, 2288 (1991). Behavioral pharmacology: C. A. Sannerud et al., Drug Alcohol Depend. 32, 195 (1993). Clinical efficacy in treatment of bulimia: H. Tamai et al., Int. J. Obes. 14, 289 (1990). Clinical evaluation of potential adverse effects: M. Suzuki et al., Jpn. J. Psychopharmacol. 13, 213 (1993); of abuse liability: S. M. Evans et al., J. Pharmacol. Exp. Ther. 271, 683 (1994). Review of pharmacology: P. A. Seymour et al., Prog. Clin. Biol. Res. 361, 453-460 (1990).
Properties: Crystals from toluene/n-hexane, mp 112-113.5°.
Melting point: mp 112-113.5°
 
Derivative Type: Citrate
CAS Registry Number: 112457-95-1
Manufacturers' Codes: SM-3997
Trademarks: Sediel (Sumitomo)
Molecular Formula: C21H29N5O2.C6H8O7
Molecular Weight: 575.61
Percent Composition: C 56.34%, H 6.48%, N 12.17%, O 25.02%
Properties: mp 169.5-170°.
Melting point: mp 169.5-170°
 
Derivative Type: Hydrochloride
Molecular Formula: C21H29N5O2.HCl
Molecular Weight: 419.95
Percent Composition: C 60.06%, H 7.20%, N 16.68%, O 7.62%, Cl 8.44%
Properties: Crystals from isopropanol, mp 227-229°.
Melting point: mp 227-229°
 
Therap-Cat: Anxiolytic; antidepressant.
Keywords: Antidepressant; Anxiolytic; Arylpiperazines; Serotonin Receptor Agonist.