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CAS No 87233-61-2 , 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole

  • Name: 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole
  • Synonyms: Emedastinum [INN-Latin]; Emedastina [INN-Spanish];1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole; Emedastine difumarate; Emedastina;Emadine; Emedastinum; Emedastine [INN];
  • CAS Registry Number:
  • Melting Point: 148-151ºC
  • Density: 1.15 g/cm3
  • Refractive index: 1.594
  • Molecular Weight: 302.41454
  • InchiKey: KBUZBQVCBVDWKX-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H26N4O/c1-3-22-14-13-21-16-8-5-4-7-15(16)18-17(21)20-10-6-9-
    19(2)11-12-20/h4-5,7-8H,3,6,9-14H2,1-2H3
  • Molecular Formula: C17H26N4O
  • Molecular Structure:CAS No:87233-61-2 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole

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References of 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole
Title: Emedastine
CAS Registry Number: 87233-61-2
CAS Name: 1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1H-benzimidazole
Synonyms: 1-[2-(ethoxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole
Molecular Formula: C17H26N4O
Molecular Weight: 302.41
Percent Composition: C 67.52%, H 8.67%, N 18.53%, O 5.29%
Literature References: Histamine H1-receptor antagonist. Prepn: R. Iemura et al., EP 79545; eidem, US 4430343 (1983, 1984 both to Kanebo); eidem, J. Med. Chem. 29, 1178 (1986). GC determn in plasma: T. Hamada et al., Chem. Pharm. Bull. 34, 1168 (1986). Series of articles on pharmacology: Arzneim.-Forsch. 34, 801-818 (1984). Toxicity data: T. Fukuda et al., ibid. 801.
 
Derivative Type: Difumarate
CAS Registry Number: 87233-62-3
Manufacturers' Codes: KB-2413; LY-188695
Trademarks: Emadine (Alcon)
Molecular Formula: C17H26N4O.2C4H4O4
Molecular Weight: 534.56
Percent Composition: C 56.17%, H 6.41%, N 10.48%, O 26.94%
Properties: Crystals from ethanol, mp 148-151°. LD50 orally in guinea pigs: 744 mg/kg (Fukuda).
Melting point: mp 148-151°
Toxicity data: LD50 orally in guinea pigs: 744 mg/kg (Fukuda)
 
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic.