Home > Name List By 3 > 3-O-methyl 5-O-(2-oxopropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate India

CAS No 86780-90-7 , 3-O-methyl 5-O-(2-oxopropyl)
2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Search by region : India

  • Name: 3-O-methyl 5-O-(2-oxopropyl)
    2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Synonyms: Sapresta; Aranidipine [INN]; Mpc-1304; DSSTox_CID_28575; CCRIS 6724; MPC 1304; NCGC00182054-02;3-O-methyl 5-O-(2-oxopropyl)
    2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; DSSTox_RID_82847; 86780-90-7;
  • CAS Registry Number:
  • Density: 1.284 g/cm3
  • Refractive index: 1.555
  • Molecular Weight: 388.3713
  • InchiKey: NCUCGYYHUFIYNU-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H20N2O7/c1-10(22)9-28-19(24)16-12(3)20-11(2)15(18(23)27-4)17
    (16)13-7-5-6-8-14(13)21(25)26/h5-8,17,20H,9H2,1-4H3
  • Molecular Formula: C19H20N2O7
  • Molecular Structure:CAS No:86780-90-7 3-O-methyl 5-O-(2-oxopropyl)<br />2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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References of 3-O-methyl 5-O-(2-oxopropyl)
2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Title: Aranidipine
CAS Registry Number: 86780-90-7
CAS Name: 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-oxopropyl ester
Synonyms: (±)-methyl 2-oxopropyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate; (±)-acetonyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate
Manufacturers' Codes: MPC-1304
Trademarks: Sapresta (Taiho)
Molecular Formula: C19H20N2O7
Molecular Weight: 388.37
Percent Composition: C 58.76%, H 5.19%, N 7.21%, O 28.84%
Literature References: Calcium channel blocker. Prepn: S. Ohno et al., FR 2514761; eidem, US 4446325 (1983, 1984 both to Maruko Seiyaku); idem et al., Chem. Pharm. Bull. 34, 1589 (1986). Pharmacology and receptor binding studies: K. Miyoshi et al., Eur. J. Pharmacol. 238, 139 (1993). Determn by GC-MS in plasma and urine: Y. Umeno et al., J. Chromatogr. 434, 123 (1988); by HPLC in plasma: Y. Iida et al., ibid. 571, 277 (1991). Cardiovascular profile: A. Kanda et al., J. Cardiovasc. Pharmacol. 22, 167 (1993). Clinical pharmacology: S. Suzuki et al., Arzneim.-Forsch. 43, 1152 (1993). Toxicity studies: S. Nakano et al., Yakuri to Chiryo 21, S931 (1993), C.A. 119, 131216 (1993).
Properties: Yellow prisms from ethyl acetate/hexane, mp 155°. LD50 in male, female mice, rats (mg/kg): 143, 193, 1982, 1459 orally; LD50 in male, female mice (mg/kg): 7.3, 9.1 i.p. (Nakano).
Melting point: mp 155°
Toxicity data: LD50 in male, female mice, rats (mg/kg): 143, 193, 1982, 1459 orally; LD50 in male, female mice (mg/kg): 7.3, 9.1 i.p. (Nakano)
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Dihydropyridine Derivatives; Calcium Channel Blocker; Dihydropyridine Derivatives.