CAS No 865-21-4 , Vinblastine Search by region : India

Name: Vinblastine
Synonyms: Vincaleukoblastine;Vinblastine;
CAS Registry Number:865-21-4
Transport: 1544
Melting Point: 211 - 216 ºC
Density: 1.37 g/cm³
Safety Statements: Human poison by intravenous route. Experimental poison by intraperitoneal route. Human systemic effects by intravenous and ocular routes: visual field changes, conjunctiva irritation and other eye effects, cardiomyopathy including infarction, and changes in bone marrow. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. Used as an antineoplastic agent. See also VINCALEUKOBLASTINE SULFATE (1:1) (SALT).
EINECS: 212-734-0
Molecular Weight: 810.97
InChI: InChI=1/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
Molecular Formula: C46H58N4O9
Molecular Structure:

Related products

Select to

865-21-4 VINBLASTINE-D3

VARDA Biotech (P) Ltd. [Manufacturer]
Tel: +91-22-6693 5686 / 2673 0141 / 2673 4258
Fax: +91-22-6693 5687
Address: 110 & 111, Kartik Complex
New link Road, Andheri-(W)
Mumbai-400053, INDIA. null,nullIndia

865-21-4 Vinblastine

CSC Pharmaceuticals Limited null
Tel: +91-(22)-4022 7098, 65966567
Fax: +91-(22)-22036884
Address: 243/ 3-B, Mangaldas Bulding, 2nd Floor, Mangaldas Road, Princess Street, Mumbai, Maharashtra 400 002, null,nullIndia

Select to

1/1

References of Vinblastine

Title: Vinblastine
CAS Registry Number: 865-21-4
CAS Name: Vincaleukoblastine
Synonyms: VLB
Molecular Formula: C46H58N4O9
Molecular Weight: 810.97
Percent Composition: C 68.13%, H 7.21%, N 6.91%, O 17.76%
Literature References: Antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. Identification: R. L. Noble et al., Ann. N.Y. Acad. Sci. 76, 882-894 (1958). Isolation and characterization: M. Gorman et al., J. Am. Chem. Soc. 81, 4745, 4754 (1959); C. T. Beer et al., US 3097137 (1963 to CPD Ltd.). Structure: N. Neuss et al., J. Am. Chem. Soc. 86, 1440 (1964). 13C-NMR spectral analysis: E. Wenkert et al., Helv. Chim. Acta 58, 1560 (1975). Synthesis from catharanthine and vindoline, q.q.v.: P. Mangeney et al., J. Am. Chem. Soc. 101, 2243 (1979); J. P. Kutney et al., Heterocycles 27, 1845 (1988). Enantioselective synthesis: M. E. Kuehne et al., J. Org. Chem. 56, 513 (1991). Toxicology: C. Lu, M. Meistrich, Cancer Res. 39, 3575 (1979). Clinical trial in combination with bleomycin, methotrexate, q.q.v. in Hodgkin's disease: P. G. Gobbi et al., J. Clin. Oncol. 14, 527 (1996). Review of pharmacology, toxicology and pharmacokinetics: W. P. Brade, Beitr. Onkol. 6, 95-123 (1981). Comprehensive description: F. J. Muhtadi, A. F. A. Afify, Anal. Profiles Drug Subs. Excip. 21, 611-658 (1992).
Properties: Solvated needles from methanol, mp 211-216°. [a]D23 -32° (c = 0.88 in methanol). uv max (ethanol): 214, 259 nm (log e 4.74, 4.22). pKa1 5.4; pKa2 7.4. Practically insol in water, petr ether. Sol in alcohols, acetone, ethyl acetate, CHCl3.
Melting point: mp 211-216°
pKa: pKa1 5.4; pKa2 7.4
Optical Rotation: [a]D23 -32° (c = 0.88 in methanol)
Absorption maximum: uv max (ethanol): 214, 259 nm (log e 4.74, 4.22)

Derivative Type: Sulfate
CAS Registry Number: 143-67-9
Manufacturers' Codes: 29060-LE
Trademarks: Exal (Nippon Kayaku); Velban (Lilly); Velbe (Lilly)
Molecular Formula: C46H58N4O9.H2SO4
Molecular Weight: 909.05
Percent Composition: C 60.78%, H 6.65%, N 6.16%, O 22.88%, S 3.53%
Properties: Crystallizes as hydrate, mp 284-285°. [a]D26 -28° (c = 1.01 in methanol). uv max (methanol): 212, 262, 284, 292 nm (log e 4.75, 4.28, 4.22, 4.18). Very slightly sol in ethanol. Practically insol in ether. One part is sol in 10 parts of water, 50 parts of chloroform. LD50 i.v. in mice: 9.5 mg/kg (Lu, Meistrich).
Melting point: mp 284-285°
Optical Rotation: [a]D26 -28° (c = 1.01 in methanol)
Absorption maximum: uv max (methanol): 212, 262, 284, 292 nm (log e 4.75, 4.28, 4.22, 4.18)
Toxicity data: LD50 i.v. in mice: 9.5 mg/kg (Lu, Meistrich)

Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products; Vinca Alkaloids.