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CAS No 84880-03-5 , Cefpimizole

  • Name: Cefpimizole
  • Synonyms: (6R,7R)-7-[[(2R)-2-[(5-carboxy-1H-imidazole-4-carbonyl)amino]-2-phenylacetyl]amino]-8-oxo-3-[[4-(2-sulfonatoethyl)pyridin-1-ium-1-yl]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;Cefpimizole;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: g/cm3
  • Flash Point: °C
  • Molecular Weight: 670.67
  • InChI: InChI=1/C28H26N6O10S2/c35-23(18(16-4-2-1-3-5-16)31-24(36)19-20(27(38)39)30-14-29-19)32-21-25(37)34-22(28(40)41)17(13-45-26(21)34)12-33-9-6-15(7-10-33)8-11-46(42,43)44/h1-7,9-10,14,18,21,26H,8,11-13H2,(H5-,29,30,31,32,35,36,38,39,40,41,42,43,44)/t18-,21-,26-/m1/s1
  • Molecular Formula: C28H26N6O10S2
  • Molecular Structure:CAS No:84880-03-5 Cefpimizole

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84880-03-5 Cefpimizole

  • China Chemrio International Limited [Manufacturer]
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84880-03-5 Cefpimizole

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84880-03-5 Pyridinium,1-[[(6R,7R)-2-carboxy-7-[[(2R)-2-[[(5-carboxy-1H-imidazol-4-yl)carbonyl]amino]-2-phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-4-(2-sulfoethyl)-,inner salt

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84880-03-5 Cefpimizole

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84880-03-5 CEFPIMIZOLE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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References of Cefpimizole
Title: Cefpimizole
CAS Registry Number: 84880-03-5
CAS Name: 1-[[(6R,7R)-2-Carboxy-7-[[(2R)-[[(5-carboxy-1H-imidazol-4-yl)carbonyl]amino]phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-4-(2-sulfoethyl)pyridinium inner salt
Synonyms: 1-[(6R,7R)-2-carboxy-7-[(R)-2-(5-carboxy-4-imidazolylcarboxamido)-2-phenylacetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-ylmethyl]pyridino-4-ethylsulfonate; 7-b-[D-(-)-a-(4-carboxyimidazole-5-carboxamido)phenylacetamido]-3-(4-b-sulfoethylpyridinium)methyl-3-cephem-4-carboxylic acid
Manufacturers' Codes: U-63196; AC-1370
Molecular Formula: C28H26N6O10S2
Molecular Weight: 670.67
Percent Composition: C 50.14%, H 3.91%, N 12.53%, O 23.86%, S 9.56%
Literature References: Third generation injectable cephalosporin antibiotic. Prepn: N. Yasuda et al., DE 2826546; eidem, US 4217450 (1979, 1980 both to Ajinomoto); N. Yasuda et al., J. Antibiot. 36, 242 (1983). In vitro antibacterial activity and b-lactamase stability: H. C. Neu, P. Labthavikul, Antimicrob. Agents Chemother. 24, 375 (1983). Potentiating effect on phagocyte functions: H. Ohnishi et al., ibid. 23, 874 (1983). Toxicity study: S. Hashimoto et al., Toxicol. Lett. 23, 135 (1984). Therapeutic efficacy in mice: Y. Obana et al., J. Antimicrob. Chemother. 16, 727 (1985). HPLC determn in human plasma and urine: D. B. Lakings, J. M. Wozniak, J. Chromatogr. 308, 261 (1984). Pharmacokinetics in humans: D. B. Lakings et al., Antimicrob. Agents Chemother. 29, 271 (1986). Efficacy and tolerance in gonorrhea in men: E. T. Sandberg et al., ibid. 849.
 
Derivative Type: Monosodium salt
CAS Registry Number: 85287-61-2
Manufacturers' Codes: U-63196E
Trademarks: Ajicef (Ajinomoto); Renilan (Mochida)
Molecular Formula: C28H25N6NaO10S2
Molecular Weight: 692.65
Percent Composition: C 48.55%, H 3.64%, N 12.13%, Na 3.32%, O 23.10%, S 9.26%
Properties: [a]D20 -28.2° (c = 0.5 in water). uv max (water): 257 nm (e 22400). Sol in water. LD50 in male, female mice, male, female rats (g/kg): 2.7, 2.9, 4.2, 3.5 i.v.; 8.2, 6.8, 12.2, 11.5 s.c.; all >15.0 orally (Hashimoto).
Optical Rotation: [a]D20 -28.2° (c = 0.5 in water)
Absorption maximum: uv max (water): 257 nm (e 22400)
Toxicity data: LD50 in male, female mice, male, female rats (g/kg): 2.7, 2.9, 4.2, 3.5 i.v.; 8.2, 6.8, 12.2, 11.5 s.c.; all >15.0 orally (Hashimoto)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.