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CAS No 84057-84-1 , 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine

  • Name: 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
  • Synonyms: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine; 84057-84-1; Lamictal Cd;Lamictal; Lamictal XR; Lamotriginum [Latin];6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine;
  • CAS Registry Number:
  • Transport: UN 2811 6
  • Melting Point: 177-181 ºC
  • Density: 1.572 g/cm3
  • Safety Statements: 45
  • Hazard Symbols: T: Toxic;
  • EINECS: 281-901-8
  • Molecular Weight: 256.09138
  • InchiKey: PYZRQGJRPPTADH-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,
    (H4,12,13,14,16)
  • Risk Statements: 25-36/37/38
  • Molecular Formula: C9H7Cl2N5
  • Molecular Structure:CAS No:84057-84-1 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine

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References of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Title: Lamotrigine
CAS Registry Number: 84057-84-1
CAS Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
Synonyms: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine; LTG
Manufacturers' Codes: BW-430C
Trademarks: Lamictal (GSK)
Molecular Formula: C9H7Cl2N5
Molecular Weight: 256.09
Percent Composition: C 42.21%, H 2.76%, Cl 27.69%, N 27.35%
Literature References: Prepn: M. G. Baxter et al., EP 21121 (1981 to Wellcome Foundation); D. A. Sawyer et al., US 4602017 (1986). HPLC determn in plasma: C.-L. Cheng et al., J. Chromatogr. B 817, 199 (2005). Anticonvulsant activity: A. A. Miller et al., Epilepsia 27, 483 (1986). Mechanism of action studies: M. J. Leach et al., ibid. 490; X. Xie, R. M. Hagan, Neuropsychobiology 38, 119 (1998). Series of articles on clinical pharmacology, antiepileptic efficacy and safety: Epilepsia 32, Suppl. 2, S1-S21 (1991). Clinical trial in bipolar depression: J. R. Calabrese et al., J. Clin. Psychiatry 60, 79 (1999). Review of clinical experience in epilepsy: H. Choi, M. J. Morrell, Expert Opin. Pharmacother. 4, 243-251 (2003); in bipolar disorder: Z. Bhagwagar, G. M. Goodwin, Expert Opin. Pharmacother. 6, 1401-1408 (2005).
Properties: White to pale cream-colored powder. Crystals from isopropanol, mp 216-218° (uncorr). pKa 5.7. Soly at 25° (mg/ml): water 0.17; 0.1M HCl 4.1. LD50 in mice, rats (mg/kg): 250, >640 orally (Sawyer).
Melting point: mp 216-218° (uncorr)
pKa: pKa 5.7
Toxicity data: LD50 in mice, rats (mg/kg): 250, >640 orally (Sawyer)
Therap-Cat: Anticonvulsant. In treatment of bipolar depression.
Keywords: Anticonvulsant.