Home > Name List By other > (2S,3aS, 7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a, 4,5,6,7,7a-octahydroindole-2-carboxylic aci...

CAS No 82834-16-0 , (2S,3aS,
7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,
4,5,6,7,7a-octahydroindole-2-carboxylic acid

  • Name: (2S,3aS,
    7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,
    4,5,6,7,7a-octahydroindole-2-carboxylic acid
  • Synonyms: S-9490; Coversum; Coverene Cor; ACEON; Prestarium;(2S,3aS,
    7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,
    4,5,6,7,7a-octahydroindole-2-carboxylic acid; Coverex; McN-A-2833; 82834-16-0;Coversyl;
  • CAS Registry Number:
  • Density: 1.15 g/cm3
  • Safety Statements: S36/37
  • Hazard Symbols: Xi
  • Molecular Weight: 368.46778
  • InchiKey: IPVQLZZIHOAWMC-QXKUPLGCSA-N
  • InChI: InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-
    13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,
    15-,16-/m0/s1
  • Risk Statements: R20/21/22
  • Molecular Formula: C19H32N2O5
  • Molecular Structure:CAS No:82834-16-0 (2S,3aS,<br />7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,<br />4,5,6,7,7a-octahydroindole-2-carboxylic acid

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82834-16-0 PERINDOPRIL

  • China Changzhou Zhongtian Chemical Co., Ltd. [Manufacturer]
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82834-16-0 PERINDOPRIL ERBUMINE

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82834-16-0; 107133-36-8 PERINDOPRIL

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82834-16-0 1H-Indole-2-carboxylicacid, 1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-,(2S,3aS,7aS)-

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82834-16-0; 107133-36-8 Perindopril Erbumine

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References of (2S,3aS,
7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,
4,5,6,7,7a-octahydroindole-2-carboxylic acid
Title: Perindopril
CAS Registry Number: 82834-16-0
CAS Name: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid
Synonyms: (2S,3aS,7aS)-1-[(S)-N-[(S)-1-carboxybutyl]alanyl]hexahydro-2-indolinecarboxylic acid 1-ethyl ester; (2S)-2-[(1S)-1-carbethoxybutylamino]-1-oxopropyl-(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
Manufacturers' Codes: S-9490; McN-A-2833
Molecular Formula: C19H32N2O5
Molecular Weight: 368.47
Percent Composition: C 61.93%, H 8.75%, N 7.60%, O 21.71%
Literature References: Angiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite. Prepn: G. Remond et al., EP 49658 (1982 to Sci. Union et Cie. - Soc. Franc. Rech. Med.); M. Vincent et al., US 4508729 (1985 to ADIR). Stereoselective synthesis: M. Vincent et al., Tetrahedron Lett. 23, 1677 (1982). NMR study: N. Platzer et al., Magn. Reson. Chem. 26, 296 (1988). Hemodynamic effects in humans: K. R. Lees, J. L. Reid, Br. J. Clin. Pharmacol. 23, 159 (1987). Clinical evaluation in essential hypertension: T. Morgan et al., J. Cardiovasc. Pharmacol. 10, Suppl. 7, S116 (1987). Pharmacokinetics, pharmacodynamics of the diacid: K. R. Lees, J. L. Reid, ibid. 10, 129 (1987). Review of pharmacology and clinical use: P. A. Todd, A. Fitton, Drugs 42, 90-114 (1991). Symposium on clinical efficacy in cardiovascular disease: Am. J. Cardiol. 88, Suppl. 1, 1-40 (2001).
 
Derivative Type: tert-Butylamine
CAS Registry Number: 107133-36-8
Synonyms: Perindopril erbumine
Manufacturers' Codes: S-9490-3; McN-A-2833-109
Trademarks: Aceon (Solvay); Coversum (Servier); Coversyl (Servier); Procaptan (Stroder)
Molecular Formula: C19H32N2O5.C4H11N
Molecular Weight: 441.60
Percent Composition: C 62.56%, H 9.81%, N 9.52%, O 18.12%
 
Derivative Type: Diacid form
CAS Registry Number: 95153-31-4
Synonyms: Perindoprilat
Manufacturers' Codes: S-9780
Molecular Formula: C17H28N2O5
Molecular Weight: 340.41
Percent Composition: C 59.98%, H 8.29%, N 8.23%, O 23.50%
 
Therap-Cat: Antihypertensive.
Keywords: ACE-Inhibitor; Antihypertensive; N-Carboxyalkyl (peptide/lactam) Derivatives.