Home > Name List By 2 > 2-(dibutylamino)-1-[(9Z)-2, 7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol

CAS No 82186-77-4 , 2-(dibutylamino)-1-[(9Z)-2,
7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol

  • Name: 2-(dibutylamino)-1-[(9Z)-2,
    7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol
  • Synonyms: Benflumetol;2-(dibutylamino)-1-[(9Z)-2,
    7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol; DSSTox_GSID_46663; NCGC00167490-01; Lumefantrine; HSDB 7210; 82186-77-4; dl-Benflumelol; DSSTox_RID_81805; DSSTox_CID_26663;
  • CAS Registry Number:
  • Density: 1.252
  • Refractive index: 1.633
  • Molecular Weight: 528.94018
  • InchiKey: DYLGFOYVTXJFJP-MYYYXRDXSA-N
  • InChI: InChI=1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25
    (15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,
    29,35H,3-6,13-14,19H2,1-2H3/b25-15-
  • Molecular Formula: C30H32Cl3NO
  • Molecular Structure:CAS No:82186-77-4 2-(dibutylamino)-1-[(9Z)-2,<br />7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol

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References of 2-(dibutylamino)-1-[(9Z)-2,
7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol
Title: Lumefantrine
CAS Registry Number: 82186-77-4
CAS Name: (9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-a-[(dibutylamino)methyl]-9H-fluorene-4-methanol
Synonyms: 2-dibutylamino-1-[2,7-dichloro-9-(4-chlorobenzylidene)-9,11-fluoren-4-yl]ethanol; dl-benflumelol; benflumetol; BFL
Manufacturers' Codes: CPG-56695
Molecular Formula: C30H32Cl3NO
Molecular Weight: 528.94
Percent Composition: C 68.12%, H 6.10%, Cl 20.11%, N 2.65%, O 3.02%
Literature References: Racemic aryl alcohol originally synthesized in the 1970's by the Academy of Military Medical Sciences in Beijing, China. Inhibits hemozoin formation. Prepn: R. Deng et al., CN 1042535 (1990 to Acad. Military Med. Sci., Microbiol. & Epidemic Dis. Instit.); C.A. 114, 6046 (1991). LC determn in plasma: A. Annerberg et al., J. Chromatogr. B 822, 330 (2005). In vitro activity against Plasmodium falciparum: B. Pradines et al., Antimicrob. Agents Chemother. 43, 418 (1999).
Properties: Odorless, yellow powder. Poorly sol in water, oil, and most organic solvents. Sol in unsaturated fatty acids.
 
Derivative Type: Co-artemether
CAS Registry Number: 141204-94-6
Manufacturers' Codes: CPG-56697
Trademarks: Coartem (Novartis); Riamet (Novartis)
Literature References: Fixed 6:1 mixture with artemether, q.v. Clinical pharmacokinetics and bioavailability: F. Ezzet et al., Br. J. Clin. Pharmacol. 46, 553 (1998). Clinical trial in children against P. falciparum malaria: C. Hatz et al., Trop. Med. Int. Health 3, 498 (1998); in adults: S. Looareesuwan et al., Am. J. Trop. Med. Hyg. 60, 238 (1999). Review of comparative clinical trials in malaria: A. A. Omari et al., Trop. Med. Int. Health 9, 192-199 (2004).
 
Therap-Cat: Antimalarial.
Keywords: Antimalarial.