Home > Name List By 2 > 2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene- 1,3-thiazolidin-3-yl]acetic acid

CAS No 82159-09-9 , 2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-
1,3-thiazolidin-3-yl]acetic acid

  • Name: 2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-
    1,3-thiazolidin-3-yl]acetic acid
  • Synonyms: Ono-2235; Epalrestat [INN]; ONO 2;2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-
    1,3-thiazolidin-3-yl]acetic acid; Epalrestatum; Epalrestatum [Latin]; Ono 2235;Kinedak; ONO-2; 82159-09-9;
  • CAS Registry Number:
  • Melting Point: 210-217 ºC
  • Flash Point: 266.4 ºC
  • Boiling Point: 516.8 ºC at 760 mmHg
  • Density: 1.43 g/cm3
  • Refractive index: 1.705
  • Water Solubility: Soluble in water
  • Flash Point: 266.4 ºC
  • Molecular Weight: 319.39862
  • InchiKey: CHNUOJQWGUIOLD-NFZZJPOKSA-N
  • InChI: InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15
    (20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
  • Molecular Formula: C15H13NO3S2
  • Molecular Structure:CAS No:82159-09-9 2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-<br />1,3-thiazolidin-3-yl]acetic acid

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References of 2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-
1,3-thiazolidin-3-yl]acetic acid
Title: Epalrestat
CAS Registry Number: 82159-09-9
CAS Name: (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid
Synonyms: 5-[(E,E)-b-methylcinnamylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid; 3-carboxymethyl-5-(2-methylcinnamylidene)rhodanine
Manufacturers' Codes: ONO-2235
Trademarks: Kinedak (Ono); Sorbistat (Ono)
Molecular Formula: C15H13NO3S2
Molecular Weight: 319.40
Percent Composition: C 56.41%, H 4.10%, N 4.39%, O 15.03%, S 20.08%
Literature References: Aldose reductase inhibitor. Prepn: T. Tadao et al., EP 47109; eidem, US 4464382 (1982, 1984 both to Ono Pharmaceutical). Inhibitory effect on aldose reductase in vitro: H. Terashima et al., J. Pharmacol. Exp. Ther. 229, 226 (1983). Effect on motor nerve conduction and sorbitol levels in diabetic rats: R. Kikkawa et al., Diabetologia 24, 290 (1983). Effect in rats on peripheral nerve dysfunction: eidem, Metabolism 33, 212 (1984); on retinal microangiopathy: K. Kojima et al., Jpn. J. Ophthalmol. 29, 99 (1985).
Properties: Crystals from ethanol-water, mp 210-217°.
Melting point: mp 210-217°
 
Derivative Type: N-Methyl-D-glucamine salt
Molecular Formula: C22H30N2O8S2
Molecular Weight: 514.61
Percent Composition: C 51.35%, H 5.88%, N 5.44%, O 24.87%, S 12.46%
Properties: Crystals from methanol, mp 163-165°.
Melting point: mp 163-165°
 
Therap-Cat: Treatment of diabetic neuropathy.
Keywords: Aldose Reductase Inhibitor.