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CAS No 82-92-8 , 1-benzhydryl-4-methylpiperazine

  • Name: 1-benzhydryl-4-methylpiperazine
  • Synonyms: Emoquil; Cyclizinum [INN-Latin]; Valoid; Ciclizina; Wellcome; Neo-devomit; Nautazine;Marezine;1-benzhydryl-4-methylpiperazine; Cyclizine hydrochloride;
  • CAS Registry Number:
  • Safety Statements: Poison by ingestion. Human systemic effects: unspecified blood effects. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • EINECS: 201-445-5
  • Molecular Weight: 266.38068
  • InchiKey: UVKZSORBKUEBAZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-
    7-11-17/h2-11,18H,12-15H2,1H3
  • Molecular Formula: C18H22N2
  • Molecular Structure:CAS No:82-92-8 1-benzhydryl-4-methylpiperazine

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82-92-8 CYCLIZINE

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82-92-8 Cyclizine hydrochloride

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82-92-8 Cyclizine Hydrochloride

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82-92-8 Cyclizine

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References of 1-benzhydryl-4-methylpiperazine
Title: Cyclizine
CAS Registry Number: 82-92-8
CAS Name: 1-Diphenylmethyl-4-methylpiperazine
Synonyms: N-benzhydryl-N￠-methylpiperazine; N-methyl-N￠-benzhydrylpiperazine; (N-benzhydryl)(N￠-methyl)diethylenediamine
Manufacturers' Codes: Compd 47-83; Wellcome prepn 47-83
Trademarks: Marzine (GlaxoWellcome); Marezine (Himmel)
Molecular Formula: C18H22N2
Molecular Weight: 266.38
Percent Composition: C 81.16%, H 8.32%, N 10.52%
Literature References: Prepn: R. Baltzly et al., J. Org. Chem. 14, 775 (1949); eidem, US 2630435 (1953 to Burroughs Wellcome). Metabolism: R. Kuntzman et al., Ann. N.Y. Acad. Sci. 226, 131 (1973). Physical properties and analysis: S. A. Benezra, Anal. Profiles Drug Subs. 6, 83 (1977). Crystallographic study: V. Bertolasi et al., Acta Crystallogr. B36, 1975 (1980). HPLC determn: R. B. Walker, I. Kanfer, J. Chromatogr. B 672, 172 (1995). Clinical antiemetic efficacy: G. Rowlands, W. J. Currie, Br. J. Clin. Pract. 30, 197 (1976); W. N. Chestnutt et al., Eur. J. Anaesthesiol. 3, 27 (1986).
Properties: Light-sensitive crystals from petr ether, mp 105.5-107.5°. uv max (0.1N HCl): 269, 263, 258, 225 (e 540, 742, 694, 11300). Soly in g/ml at 25°: chloroform 1.1; ether 0.17; ethanol 0.17; in mg/ml: water <0.1.
Melting point: mp 105.5-107.5°
Absorption maximum: uv max (0.1N HCl): 269, 263, 258, 225 (e 540, 742, 694, 11300)
 
Derivative Type: Hydrochloride
CAS Registry Number: 303-25-3
Trademarks: Valoid (Glaxo Wellcome)
Molecular Formula: C18H22N2.HCl
Molecular Weight: 302.84
Percent Composition: C 71.39%, H 7.66%, N 9.25%, Cl 11.71%
Properties: Crystals, moderately sol in water. Protect from light.
 
Therap-Cat: Antiemetic.
Therap-Cat-Vet: Antiemetic.
Keywords: Antiemetic.