Home > Name List By other > (6aR,9R, 10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a, 8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quino...

CAS No 81409-90-7 , (6aR,9R,
10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,
8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

  • Name: (6aR,9R,
    10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,
    8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
  • Synonyms: Cabergolina; FCE-21336;(6aR,9R,
    10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,
    8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide; Cabergolinum; Galastop; Cabergolinum [Latin]; Cabergolina [Spanish]; Cabaseril;Dostinex; Cabaser;
  • CAS Registry Number:
  • Density: 1.156 g/cm3
  • Refractive index: 1.594
  • Water Solubility: Insoluble in water
  • Molecular Weight: 451.60428
  • InchiKey: KORNTPPJEAJQIU-KJXAQDMKSA-N
  • InChI: InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)
    4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,
    23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1
  • Molecular Formula: C26H37N5O2
  • Molecular Structure:CAS No:81409-90-7 (6aR,9R,<br />10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,<br />8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

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81409-90-7 (6aR,9R, 10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a, 8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

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81409-90-7 (6aR,ethylcarbamoyl)-7-prop-2-enyl-6,6a, 8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

  • Cabergoline CAS: 81409-90-7 Cabergoline MF: C26H37N5O2 Cabergoline MW: 451.6 Cabergoline Melting Point: 102-104℃ Cabergoline Chemical properties: Cabergoline is a white powder soluble in ethyl alcohol, chloroform, and D
  • China Hubei Yuancheng Saichuang Technology Co,Ltd [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: 86-188-72220799
  • Address: No.496 ZhongShan Road, Wuchang District, Wuhan,Hubei wuhan,HubeiChina
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81409-90-7 Cabergoline Alias: Cabaser,Dostinex;Dostine CAS: 81409-90-7

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    • China Jinan Jiage Biological Techonlogy Co, Ltd [Manufacturer, Trading Company]
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    References of (6aR,9R,
    10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,
    8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
    Title: Cabergoline
    CAS Registry Number: 81409-90-7
    CAS Name: (8b)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8-carboxamide
    Synonyms: 1-ethyl-3-(3￠-dimethylaminopropyl)-3-(6￠-allylergoline-8￠b-carbonyl)urea; 1-[(6-allylergoline-8b-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
    Manufacturers' Codes: FCE-21336
    Trademarks: Dostinex (Pharmacia & Upjohn)
    Molecular Formula: C26H37N5O2
    Molecular Weight: 451.60
    Percent Composition: C 69.15%, H 8.26%, N 15.51%, O 7.09%
    Literature References: Dopamine D2-receptor agonist. Prepn: P. Salvati et al., BE 888243; eidem, US 4526892 (1981, 1985 both to Farmitalia Carlo Erba). Prepn and bioactivity: E. Brambilla et al., Eur. J. Med. Chem. 24, 421 (1989). Clinical pharmacology: C. Ferrari et al., J. Clin. Endocrinol. Metab. 63, 941 (1986). Veterinary trial as abortifacient in dogs: K. Post et al., Theriogenology 29, 1233 (1988). Clinical evaluation to prevent puerperal lactation: G. B. Melis et al., Obstet. Gynecol. 71, 311 (1988); in hyperprolactinemic disorders: C. Ferrari et al., J. Clin. Endocrinol. Metab. 68, 1201 (1989). Clinical trial in Parkinson's disease: J. T. Hutton et al., Neurology 46, 1062 (1996).
    Properties: White crystals from diethyl ether, mp 102-104°. Sol in ethyl alcohol, chloroform, DMF; slightly sol in 0.1 N HCl; very slightly sol in n-hexane. Insol in water. LD50 orally in male mice: >400 mg/kg (Brambilla).
    Melting point: mp 102-104°
    Toxicity data: Sol in ethyl alcohol, chloroform, DMF; slightly sol in 0.1 N HCl; very slightly sol in n-hexane. Insol in water. LD50 orally in male mice: >400 mg/kg (Brambilla)
     
    Derivative Type: Diphosphate
    CAS Registry Number: 85329-89-1
    Molecular Formula: C26H37N5O2.2H3PO4
    Molecular Weight: 647.59
    Percent Composition: C 48.22%, H 6.69%, N 10.81%, O 24.71%, P 9.57%
    Properties: mp 153-155°.
    Melting point: mp 153-155°
     
    Therap-Cat: Prolactin inhibitor; antiparkinsonian.
    Therap-Cat-Vet: Prolactin inhibitor.
    Keywords: Antiparkinsonian; Dopamine Receptor Agonist; Prolactin Inhibitor.