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CAS No 81103-11-9 , Clarithromycin Search by region : India

  • Name: Clarithromycin
  • Synonyms: Klacid; A-56268;Clarithromycin; A-56268; Biaxin; Klacid; TE-03; TE-03;6-O-Methylerythromycin; Biaxin;
  • CAS Registry Number:
  • Transport: MAC
  • Melting Point: 217-220 ºC
  • Density: 1.18 g/cm3
  • Refractive index: -92 ° (C=1, CHCl3)
  • Water Solubility: Insoluble
  • Safety Statements: 26-36
  • Hazard Symbols: Xi: Irritant;Xn: Harmful;
  • HS Code: 29419000
  • Molecular Weight: 747.96
  • InChI: InChI=1/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20?,21+,22+,23-,24?,25?,26-,27?,29?,30+,31-,32?,33-,35?,36?,37-,38-/m1/s1
  • Risk Statements: 22-36/37/38
  • Molecular Formula: C38H69NO13
  • Molecular Structure:CAS No:81103-11-9 Clarithromycin

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References of Clarithromycin
Title: Clarithromycin
CAS Registry Number: 81103-11-9
CAS Name: 6-O-Methylerythromycin
Manufacturers' Codes: A-56268; TE-031
Trademarks: Biaxin (Abbott); Clarosip (Grñenthal); Clathromycin (Taisho); Cyllind (Abbott); Klacid (Abbott); Klaricid (Abbott); Macladin (Guidotti); Naxy (Sanofi Winthrop); Veclam (Zambon); Zeclar (Abbott)
Molecular Formula: C38H69NO13
Molecular Weight: 747.95
Percent Composition: C 61.02%, H 9.30%, N 1.87%, O 27.81%
Literature References: Semisynthetic macrolide antibiotic; derivative of erythromycin, q.v. Prepn: Y. Watanabe et al., EP 41355; eidem, US 4331803 (1981, 1982 both to Taisho); and in vitro antibacterial activity: S. Morimoto et al., J. Antibiot. 37, 187 (1984). In vitro and in vivo antibacterial activity: P. B. Fernandes et al., Antimicrob. Agents Chemother. 30, 865 (1986). Comparative antibacterial spectrum in vitro: C. Benson et al., Eur. J. Clin. Microbiol. 6, 173 (1987); H. M. Wexler, S. M. Finegold, ibid. 492. HPLC determn in biological fluids: D. Croteau et al., J. Chromatogr. 419, 205 (1987); in plasma: H. Amini, A. Ahmadiani, J. Chromatogr. B 817, 193 (2005). Acute toxicity study: S. Abe et al., Chemotherapy (Tokyo) 36, Suppl. 3, 274 (1988). Symposium on pharmacology and comparative clinical studies: J. Antimicrob. Chemother. 27, Suppl. A, 1-124 (1991). Comprehensive description: I. I. Salem, Anal. Profiles Drug Subs. Excip. 24, 45-85, (1996).
Properties: Colorless needles from chloroform + diisopropyl ether (1:2), mp 217-220° (dec). Also reported as crystals from ethanol, mp 222-225° (Morimoto). uv max (CHCl3): 288 nm (e 27.9). uv max (CHCl3): 240, 288 nm; (methanol): 211, 288 nm. [a]D24 -90.4° (c = 1 in CHCl3). Stable at acidic pH. LD50 in male, female mice, male, female rats (mg/kg): 2740, 2700, 3470, 2700 orally, 1030, 850, 669, 753 i.p., >5000 all s.c. (Abe).
Melting point: mp 217-220° (dec); mp 222-225° (Morimoto)
Optical Rotation: [a]D24 -90.4° (c = 1 in CHCl3)
Absorption maximum: uv max (CHCl3): 288 nm (e 27.9). uv max (CHCl3): 240, 288 nm
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 2740, 2700, 3470, 2700 orally, 1030, 850, 669, 753 i.p., >5000 all s.c. (Abe)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Macrolides.