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CAS No 8052-16-2 , Actinomycin C

  • Name: Actinomycin C
  • Synonyms: 1H-Pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecine, cyclic peptidederiv.; NSC 87222;Sanamycin; HBF 386; NSC 18268; 3H-Phenoxazine, actinomycin C deriv.;Cactinomycin(8CI);Actinomycin C;
  • CAS Registry Number:
  • Transport: UN 3462 6.1/PG 2
  • Flash Point: 793.4°C
  • Boiling Point: 1388.3°Cat760mmHg
  • Density: 1.41g/cm3
  • Safety Statements: Deadly poison by intravenous, parenteral, intraperitoneal, and possibly other routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. An antibiotic.
  • Hazard Symbols: T+
  • Flash Point: 793.4°C
  • EINECS: 232-485-1
  • Molecular Weight: 1260.62
  • InChI: InChI=1/C63H88N12O16/c1-17-31(8)44-61(86)75-25-19-21-38(75)59(84)71(14)27-40(77)73(16)50(30(6)7)63(88)90-35(12)46(57(82)67-44)69-55(80)41-42(64)51(78)33(10)53-48(41)65-47-36(23-22-32(9)52(47)91-53)54(79)68-45-34(11)89-62(87)49(29(4)5)72(15)39(76)26-70(13)58(83)37-20-18-24-74(37)60(85)43(28(2)3)66-56(45)81/h22-23,28-31,34-35,37-38,43-46,49-50H,17-21,24-27,64H2,1-16H3,(H,66,81)(H,67,82)(H,68,79)(H,69,80)/t31-,34+,35+,37-,38-,43-,44-,45-,46-,49-,50-/m0/s1
  • Risk Statements: 46-61-26/27/28
  • Molecular Formula: C62H89N11O17
  • Molecular Structure:CAS No:8052-16-2 Actinomycin C

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8052-16-2 ACTINOMYCIN C

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References of Actinomycin C
Title: Cactinomycin
CAS Registry Number: 8052-16-2
CAS Name: Actinomycin C
Manufacturers' Codes: HBF-386
Trademarks: Sanamycin (FBA Pharm)
Literature References: Antibiotic complex produced by Streptomyces chrysomallus: Brockmann, Grubhofer, Naturwissenschaften 36, 376 (1949); 37, 494 (1950); Ber. 84, 260 (1951); US 2953495 (1960 to Shenley Inds.); Lindenbein, Arch. Mikrobiol. 17, 361 (1952). Mixture of actinomycins C1 (dactinomycin, q.v.), C2 and C3, 10%, 45% and 45%, resp: Brockmann, Pfennig, Naturwissenschaften 39, 429 (1952); Brockmann, Gr?ne, ibid. 40, 222 (1953). Description of other actinomycins: Waksman et al., Proc. Natl. Acad. Sci. USA 44, 602 (1958). Structures: Brockmann et al., Angew. Chem. 68, 70 (1956); Brockmann, Boldt, Naturwissenschaften 50, 19 (1963). Synthesis of actinomycin C3: Brockmann, Lackner, ibid. 47, 230 (1960); 48, 555 (1961); 51, 407 (1964); Brockmann et al., DE 1172680 (1964 to Bayer); Brockmann, Lackner, Ber. 100, 353 (1967); 101, 1312 (1968). Synthesis of actinomycin C2: Brockmann, Lackner, Tetrahedron Lett. 1964, 3517. Comprehensive review: H. Brockmann, in Fortschr. Chem. Org. Naturst. 18, 1-54 (1960).
Properties: Alizarin-red hexagonal bipyramids from ethyl acetate, mp 252°. [a]D25 -325 to -349° (c = 0.25 in ethanol). Sparingly sol in water; moderately sol in ethanol; sol in chloroform, ethyl acetate, benzene, acetone. Protect from light.
Melting point: mp 252°
Optical Rotation: [a]D25 -325 to -349° (c = 0.25 in ethanol)
 
Derivative Type: Actinomycin C2
Molecular Formula: C63H88N12O16
Molecular Weight: 1269.44
Percent Composition: C 59.61%, H 6.99%, N 13.24%, O 20.17%
Properties: Red bipyramids, prisms or needles from ethyl acetate, mp 237-239°. [a]D21 -325 ±10° (c = 0.23 in methanol). Abs max (methanol): 443 nm (e 25400).
Melting point: mp 237-239°
Optical Rotation: [a]D21 -325 ±10° (c = 0.23 in methanol)
Absorption maximum: Abs max (methanol): 443 nm (e 25400)
 
Derivative Type: Actinomycin C3
Molecular Formula: C64H90N12O16
Molecular Weight: 1283.47
Percent Composition: C 59.89%, H 7.07%, N 13.10%, O 19.95%
Properties: Red hexagonal bipyramids from ethyl acetate or methanol, dec 235°. [a]D17 -328° (c = 0.5 in ethanol). Absorption max (methanol): 443 nm (e 24100). Weak base.
Optical Rotation: [a]D17 -328° (c = 0.5 in ethanol)
Absorption maximum: Absorption max (methanol): 443 nm (e 24100)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antibiotics and Analogs; Actinomycins.