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CAS No 79944-58-4 , 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole

  • Name: 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole
  • Synonyms: 79944-58-4; Idazoxanum;2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole; Idazoxano [Spanish];Idazoxane; Idazoxano; Idazoxane [French]; Idazoxanum [Latin]; CHEBI:5862;
  • CAS Registry Number:
  • Density: 1.39 g/cm3
  • Refractive index: 1.665
  • Molecular Weight: 204.22518
  • InchiKey: HPMRFMKYPGXPEP-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,
    10H,5-7H2,(H,12,13)
  • Molecular Formula: C11H12N2O2
  • Molecular Structure:CAS No:79944-58-4 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole

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References of 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole
Title: Idazoxan
CAS Registry Number: 79944-58-4
CAS Name: 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole
Synonyms: 2-[2-(1,4-benzodioxanyl)]-2-imidazoline
Molecular Formula: C11H12N2O2
Molecular Weight: 204.23
Percent Composition: C 64.69%, H 5.92%, N 13.72%, O 15.67%
Literature References: a2-Adrenergic blocker. Prepn: J. Krapcho, W. A. Lott, US 2979511 (1961 to Olin Mathieson); and confirmation of structure: C. B. Chapleo, P. L. Myers, Tetrahedron Lett. 22, 4839 (1981). Structure-activity study: C. B. Chapleo et al., J. Med. Chem. 26, 823 (1983). Pharmacology: H. Dabiré, J. Pharmacol. 17, 113 (1986). Clinical evaluation in progressive supranuclear palsy: D. G. Cole, J. H. Growdon, J. Neural Transm. Suppl. 42, 283 (1994); as adjunct to fluphenazine in schizophrenia: R. E. Litman et al., Br. J. Psychiatry 168, 571 (1996).
 
Derivative Type: Hydrochloride
CAS Registry Number: 79944-56-2
Manufacturers' Codes: RX-781094
Molecular Formula: C11H12N2O2.HCl
Molecular Weight: 240.69
Percent Composition: C 54.89%, H 5.44%, N 11.64%, O 13.29%, Cl 14.73%
Properties: White, crystalline solid from isopropanol, mp 207-208°.
Melting point: mp 207-208°
 
Therap-Cat: Antiparkinsonian.
Keywords: a-Adrenergic Blocker; Antiparkinsonian.