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CAS No 79350-37-1 , Cefixime

  • Name: Cefixime
  • Synonyms: Suprax;(6R,7R)-7-(2-(2-Amino-4-thiazolyl)gloxylamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7(square)-(Z)-(O-(carboxymethyl)oxime)-trihydrate;Cefixime; Cefixime main-ring;
  • CAS Registry Number:
  • Density: 1.85 g/cm3
  • Water Solubility: 55.11 mg/L
  • Safety Statements: 22-36/37-45
  • Hazard Symbols: Xn: Harmful;
  • Molecular Weight: 453.45
  • InChI: InChI=1/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9+/t10-,14-/m1/s1
  • Risk Statements: 42/43
  • Molecular Formula: C16H15N5O7S2
  • Molecular Structure:CAS No:79350-37-1 Cefixime

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References of Cefixime
Title: Cefixime
CAS Registry Number: 79350-37-1
CAS Name: (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: 7-[2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid
Manufacturers' Codes: FK-027; FR-17027; CL-284635
Trademarks: Cefixoral (Menarini); Cefspan (Fujisawa); Cephoral (Merck KGaA); Oroken (Bellon); Suprax (Wyeth); Unixime (Firma)
Molecular Formula: C16H15N5O7S2
Molecular Weight: 453.45
Percent Composition: C 42.38%, H 3.33%, N 15.44%, O 24.70%, S 14.14%
Literature References: Orally active, third generation cephalosporin antibiotic. Prepn: T. Takaya et al., EP 30630; eidem, US 4409214 (1981, 1983 both to Fujisawa); H. Yamanaka et al., J. Antibiot. 38, 1738 (1985). Synthesis and activity of (E)-isomer: K. Kawabata et al., Chem. Pharm. Bull. 34, 3458 (1986). Mechanism of action: Y. Shigi et al., J. Antibiot. 37, 790 (1984). Comparative antibacterial spectrum in vitro and in vivo: T. Kamimura et al., Antimicrob. Agents Chemother. 25, 98 (1984). In vitro activity and b-lactamase stability: H. C. Neu et al., ibid. 26, 174 (1984). HPLC determn in human plasma and urine: Y. Tokuma et al., J. Chromatogr. 311, 339 (1984). Pharmacokinetics in humans: D. R. P. Guay et al., Antimicrob. Agents Chemother. 30, 485 (1986). Clinical trial in urinary tract infections: J. Levenstein et al., S. Afr. Med. J. 70, 455 (1986); A. Irvani et al., Am. J. Med. 85, Suppl. 3A, 17 (1988); in respiratory infections: R. Kiani et al., ibid. 6.
 
Derivative Type: (Z)-Form disodium salt
Molecular Formula: C16H13N5Na2O7S2
Molecular Weight: 497.41
Percent Composition: C 38.63%, H 2.63%, N 14.08%, Na 9.24%, O 22.52%, S 12.89%
Properties: mp >250°.
Melting point: mp >250°
 
Derivative Type: (E)-Form trihydrate
Properties: Pale yellow solid, mp 218-225° (dec).
Melting point: mp 218-225° (dec)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.