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CAS No 78967-07-4 , 2-[3,4-bis(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid

  • Name: 2-[3,4-bis(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid
  • Synonyms: 78967-07-4; CCRIS 4316; N-22; 3,4-bis(4-methoxyphenyl)-;2-[3,4-bis(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid; Mofezolaco [INN-Spanish]; 5-Isoxazoleacetic acid; Mofezolacum [INN-Latin];
  • CAS Registry Number:
  • Flash Point: 272.7°C
  • Boiling Point: 527.2°C at 760 mmHg
  • Density: 1.25g/cm3
  • Refractive index: 1.579
  • Flash Point: 272.7°C
  • Molecular Weight: 339.34198
  • InchiKey: DJEIHHYCDCTAAH-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H17NO5/c1-23-14-7-3-12(4-8-14)18-16(11-17(21)22)25-20-19(18)
    13-5-9-15(24-2)10-6-13/h3-10H,11H2,1-2H3,(H,21,22)
  • Molecular Formula: C19H17NO5
  • Molecular Structure:CAS No:78967-07-4 2-[3,4-bis(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid

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References of 2-[3,4-bis(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid
Title: Mofezolac
CAS Registry Number: 78967-07-4
CAS Name: 3,4-Bis(4-methoxyphenyl)-5-isoxazoleacetic acid
Synonyms: 3,4-di(p-methoxyphenyl)-5-isoxazoleacetic acid
Manufacturers' Codes: N-22
Molecular Formula: C19H17NO5
Molecular Weight: 339.34
Percent Composition: C 67.25%, H 5.05%, N 4.13%, O 23.57%
Literature References: Prostaglandin biosynthetase inhibitor. Prepn: R. G. Micetich et al., EP 26928; eidem, US 4327222 (1981, 1982 both to CDC Life Sci.). Physico-chemical properties: T. Ushio et al., Iyakuhin Kenkyu 22, 892 (1991). HPLC determn in plasma and urine: T. Marunaka, M. Maniwa, J. Chromatogr. 422, 227 (1987). Pharmacology: K. Tanaka et al., Yakuri to Chiryo 18, 3347 (1990), C.A. 114, 135911 (1991). Acute toxicity: K. Satoh et al., J. Toxicol. Sci. 15, Suppl 2, 1 (1990).
Properties: White crystalline powder; slight characteristic odor. mp 147.5°. pKa￠ ~3.3. uv max (methanol): 236 nm (e = 1.83 ′ 104). Soly at 20° (w/v%): DMF 68.7; chloroform 19.5; ethyl acetate 16.5; acetone 7.32; methanol 3.93; anhydr ethanol 3.72; ether 2.90; hexane 2.90 ′ 10-5; water 4.85 ′ 10-3. Partition coefficient (chloroform/water): 16.6 (pH 6); 1.87 (pH 7); 0.178 (pH 8). LD50 in male, female mice, male, female rats (mg/kg): 1528, 1740, 920, 887 orally; 275, 321, 378, 342 i.p.; 612, 545, 572, 510 s.c. (Satoh).
Melting point: mp 147.5°
pKa: pKa￠ ~3.3
Log P: Partition coefficient (chloroform/water): 16.6 (pH 6); 1.87 (pH 7); 0.178 (pH 8)
Absorption maximum: uv max (methanol): 236 nm (e = 1.83 ′ 104)
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 1528, 1740, 920, 887 orally; 275, 321, 378, 342 i.p.; 612, 545, 572, 510 s.c. (Satoh)
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.